PERINORM CD CAPSULE

💊🌪️ Metoclopramide 15 mg Tablet

“Targeted Motion Relief & Digestive Support”
Powerful Antiemetic | Prokinetic Action | Controlled Therapy

---

📋 What is Metoclopramide 15 mg?

Metoclopramide 15 mg is a centrally and peripherally acting dopamine antagonist used as an antiemetic (prevents nausea/vomiting) and prokinetic agent (stimulates upper GI motility). The 15 mg strength is typically reserved for moderate to severe symptoms or cases requiring higher-dose therapy under close supervision.

It improves gastric emptying, increases lower esophageal sphincter tone, and blocks dopamine receptors in the brain to suppress nausea signals.

---

🔬 Active Ingredient

• Metoclopramide hydrochloride 15 mg

  • Class: Dopamine D2 receptor antagonist

  • Mechanism of Action:

    • Enhances gastric and duodenal motility

    • Blocks dopamine in the chemoreceptor trigger zone (CTZ) in the brain

    • Increases esophageal sphincter pressure, preventing reflux

---

💡 Therapeutic Uses / Indications

Metoclopramide 15 mg is indicated for:

• Nausea and vomiting (postoperative, chemotherapy, radiation therapy)

• Diabetic gastroparesis

• Gastroesophageal reflux disease (GERD) unresponsive to other treatments

• Delayed gastric emptying

• Migraine-associated nausea

• To facilitate barium meal GI imaging

---

🕒 How to Use

• Dosage:

  • 15 mg tablet taken up to 3 times a day (maximum 45 mg/day)

  • Generally 30 minutes before meals and/or at bedtime

• Duration: Short-term use recommended (no longer than 12 weeks)

• Route: Oral; swallow with water, with or without food

⚠️ Higher doses should only be used under close medical supervision due to increased risk of neurological side effects.

---

✅ Common Side Effects

• Drowsiness or fatigue

• Headache

• Restlessness or agitation

• Diarrhea or loose stools

• Increased frequency of urination

---

🚨 Serious Side Effects (Rare but Important)

• Extrapyramidal Symptoms (EPS):

  • Involuntary muscle spasms, facial twitching, neck stiffness

• Tardive Dyskinesia:

  • Involuntary, repetitive movements (mouth, tongue, face); risk increases with prolonged use

• Neuroleptic Malignant Syndrome (NMS):

  • A rare but serious neurologic emergency

• Depression, suicidal thoughts in predisposed individuals

• Allergic Reactions: Rash, swelling, breathing difficulty

---

🔍 Monitoring & Follow-Up

• Neurological evaluation for involuntary movements, especially in long-term use

• Monitor for mood changes, fatigue, or sedation

• Liver function tests in chronic use

• Diabetic patients: Monitor gastric symptoms and blood sugar control

• Discontinue if any EPS or movement disorder is suspected

---

⚠️ Warnings & Precautions

• Use for ≤12 weeks to minimize tardive dyskinesia risk

• Contraindicated in:

  • Parkinson’s disease

  • Epilepsy or seizure disorders

  • GI obstruction, perforation, or bleeding

  • Pheochromocytoma (can trigger hypertensive crisis)

• Avoid alcohol and sedatives—increased drowsiness

• Not recommended in children unless specifically directed

• Caution in elderly—higher risk for EPS and confusion

• Use in pregnancy only when benefits outweigh risks

---

📝 Summary

Metoclopramide 15 mg Tablet is a potent gastrointestinal prokinetic and antiemetic agent, ideal for short-term treatment of severe nausea, gastroparesis, or reflux unresponsive to standard therapy. While it offers fast and effective relief, the risk of neurological side effects such as tardive dyskinesia makes proper monitoring, dose limitation, and medical supervision essential.

Used responsibly, it helps restore gastric rhythm and comfort, especially in patients suffering from diabetic gastric stasis or persistent nausea.

---

🌟🔄 “When the Gut Slows, Metoclopramide Goes to Work”

Enhanced Motility. Reduced Nausea. Controlled Relief.

---

Always follow your doctor’s advice, dosage instructions, and never self-medicate.