EBASIL TABLET

🌸🤧💊 Ebastine 10mg Tablet: Fast-Acting Antihistamine for Allergy Relief

Ebastine 10mg is a second-generation antihistamine used for the treatment of allergic conditions such as allergic rhinitis (hay fever), urticaria (hives), and other histamine-related symptoms like sneezing, nasal congestion, watery eyes, itching, and skin rashes. It offers long-lasting, non-sedating relief by selectively blocking H1 histamine receptors, making it ideal for daily allergy management without impairing alertness.

Ebastine is widely favored for its rapid onset, 24-hour efficacy, and minimal central nervous system side effects, making it a preferred option for both adults and children (in appropriate formulations).

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🔬 Mechanism of Action

Ebastine works by selectively antagonizing histamine H1 receptors in the respiratory tract, skin, and mucous membranes. Histamine is a chemical released during allergic reactions that causes symptoms like itching, inflammation, runny nose, and swelling.

Ebastine:

• Blocks histamine action at receptor sites

• Reduces vascular permeability, edema, and nasal secretions

• Relieves itching, rash, and nasal congestion

• Does not cross the blood-brain barrier significantly, thus avoiding sedation

It is metabolized in the liver to its active form carebastine, which maintains the therapeutic effects for up to 24 hours after a single dose.

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📌 Indications and Uses

Ebastine 10mg is commonly used to treat:

• Seasonal allergic rhinitis (pollen allergies/hay fever)

• Perennial allergic rhinitis (dust mites, pet dander)

• Chronic idiopathic urticaria (hives without known cause)

• Dermatological allergic conditions

• Allergic conjunctivitis (watery, itchy eyes – supportive therapy)

It provides effective daytime allergy relief due to its low sedative potential.

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💊 Dosage and Administration

• Adults and adolescents (≥12 years): One 10mg tablet once daily

• Can be increased to 20mg once daily in severe cases (as per doctor’s advice)

• With or without food

• Tablets should be swallowed whole, not chewed or split

Not recommended for children below 12 years in tablet form (use pediatric syrup formulation if needed).

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⚠️ Precautions and Warnings

• Use with caution in:

  • Liver disease (as it is metabolized hepatically)

  • Heart rhythm disorders (rare risk of QT prolongation at high doses)

• Safe for most adults; minimal sedative effects in comparison to first-generation antihistamines

• Pregnancy and breastfeeding: Use only if clearly needed and prescribed

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🤒 Side Effects

Common (usually mild and self-limiting):

• Headache

• Dry mouth

• Drowsiness (rare)

• Abdominal pain

Rare but serious:

• Palpitations or irregular heartbeat (at high doses)

• Allergic reactions (rash, swelling, difficulty breathing – very rare)

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🔄 Drug Interactions

• Avoid use with:

  • Ketoconazole, erythromycin, or other CYP3A4 inhibitors (may increase blood levels of Ebastine)

• Caution with alcohol or other CNS depressants (may slightly increase drowsiness)

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🧊 Storage Instructions

• Store at 15–25°C in a dry place, away from direct sunlight

• Keep out of reach of children

• Do not use past expiration date

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📝 Conclusion

Ebastine 10mg tablet provides effective, non-sedating relief from allergy symptoms including rhinitis, urticaria, and skin allergies. Its once-daily dosing, rapid action, and low side-effect profile make it a reliable choice for long-term allergy management, allowing patients to maintain a normal, active lifestyle without daytime drowsiness.