ENZYL 160 CAPSULE

🧬🛡️💊 Enzalutamide 160mg Tablet: Advanced Oral Therapy for Prostate Cancer Control

Enzalutamide 160mg is a hormonal anticancer medication used in the treatment of prostate cancer, especially in castration-resistant and metastatic hormone-sensitive prostate cancer (mHSPC). It belongs to the class of drugs known as androgen receptor inhibitors, specifically developed to block the effects of male hormones (androgens) such as testosterone on prostate cancer cells. By doing so, Enzalutamide slows down or stops the growth and spread of the cancer.

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🔬 Mechanism of Action

Enzalutamide works by inhibiting the androgen receptor (AR) at multiple stages of the signaling pathway:

• It competitively blocks androgen (testosterone and dihydrotestosterone) binding to the receptor.

• Prevents androgen receptor nuclear translocation, stopping it from reaching the cell nucleus.

• Inhibits DNA binding and activation of target genes necessary for cancer cell growth.

By disrupting these pathways, Enzalutamide reduces tumor cell proliferation, delays disease progression, and improves overall survival in men with advanced prostate cancer.

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📌 Indications and Uses

Enzalutamide 160mg is indicated for the treatment of:

• Metastatic castration-resistant prostate cancer (mCRPC)

• Non-metastatic castration-resistant prostate cancer (nmCRPC)

• Metastatic hormone-sensitive prostate cancer (mHSPC)

It is used in combination with ongoing androgen deprivation therapy (ADT), such as surgical castration or the use of GnRH agonists (e.g., leuprolide).

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💊 Dosage and Administration

• Standard adult dose: 160mg once daily, taken as four 40mg tablets

• Should be taken at the same time each day, with or without food

• Tablets must be swallowed whole, not crushed or chewed

• Continue ADT throughout Enzalutamide therapy unless surgically castrated

Missed doses should be taken as soon as remembered unless it’s almost time for the next dose.

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⚠️ Precautions and Warnings

• Not recommended in women or children

• May cause seizures (rare) – avoid driving or operating heavy machinery if affected

• Use caution in patients with:

  • History of cardiovascular disease

  • Hypertension

  • Seizure disorders or brain metastases

• Monitor liver function periodically

• Not advised during pregnancy or lactation – harmful to the fetus

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🤒 Side Effects

Common:

• Fatigue or weakness

• Hot flashes

• Hypertension

• Back or joint pain

• Decreased appetite

• Diarrhea or constipation

Serious/Rare:

• Seizures

• Falls and fractures (especially in elderly)

• Heart problems

• Posterior reversible encephalopathy syndrome (PRES) – a rare neurological condition

Inform a doctor if there are signs of confusion, vision changes, severe headache, or seizures.

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🔄 Drug Interactions

• Enzalutamide is a strong CYP3A4 inducer, which may reduce the effectiveness of many drugs like:

  • Warfarin

  • Anticonvulsants

  • Certain cholesterol-lowering drugs

• Avoid CYP2C8 inhibitors like gemfibrozil (may increase Enzalutamide levels)

• Use with caution with drugs that lower the seizure threshold

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🧊 Storage Instructions

• Store at room temperature (20–25°C)

• Protect from light and moisture

• Keep out of reach of children

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📝 Conclusion

Enzalutamide 160mg tablet is a targeted, effective oral therapy for advanced prostate cancer. It provides significant clinical benefit by blocking androgen-driven tumor growth while allowing patients to maintain a better quality of life compared to traditional chemotherapy. With proper monitoring and medical guidance, Enzalutamide offers a powerful defense against disease progression in hormone-dependent prostate cancer.