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SUPIROCIN OINTMENT

Original price was: ₹113.62.Current price is: ₹101.12.

SUPIROCIN OINTMENT

Mupirocin 2%

Glenmark Pharmaceuticals Ltd

Description

Description

🧴🦠🛡️ Mupirocin 2%: Topical Antibiotic for Skin Infections and Nasal Decolonization

Mupirocin 2% is a topical antibiotic used to treat a variety of bacterial skin infections and for nasal decolonization of MRSA (Methicillin-resistant Staphylococcus aureus). It is available in ointment or cream form for dermatological use and as a nasal ointment to reduce the spread of MRSA in healthcare settings. Mupirocin is highly effective against Gram-positive bacteria, especially Staphylococcus aureus and Streptococcus pyogenes, making it a trusted medication in both outpatient and hospital environments.


🔬 Mechanism of Action

Mupirocin works by inhibiting bacterial isoleucyl-tRNA synthetase, an enzyme critical for bacterial protein synthesis. This action:

  • Prevents bacteria from producing proteins

  • Stops bacterial growth (bacteriostatic) at low concentrations

  • Kills bacteria (bactericidal) at higher concentrations

It is highly selective for bacterial cells, with minimal effect on human cells, making it suitable for localized treatment.


📌 Indications and Uses

🔹 Topical (Skin) Use – 2% Cream/Ointment:

  • Impetigo: highly contagious skin infection, especially in children

  • Folliculitis: inflammation of hair follicles

  • Furunculosis (boils) and carbuncles

  • Infected eczema

  • Minor wounds, cuts, burns, or abrasions with secondary infection

  • Staphylococcal skin infections (e.g., MRSA colonization on skin)

🔹 Nasal Ointment Use (specifically formulated 2% ointment):

  • Eradication of nasal carriage of MRSA

  • Used in pre-operative decolonization protocols to reduce post-surgical infections

  • Often part of infection control in hospitals and ICUs


💊 Dosage and Administration

Topical application:

  • Apply a small amount of Mupirocin 2% cream or ointment to the affected area 2 to 3 times daily

  • Treated area may be covered with a gauze dressing if necessary

  • Duration: Usually 5 to 10 days

Nasal application:

  • A small amount (~match-head size) is applied inside each nostril twice daily for 5 days

  • Patient should close nostrils and gently press to spread the ointment evenly

Wash hands before and after use. Avoid contact with eyes, mouth, or mucous membranes unless prescribed.


⚠️ Precautions and Warnings

  • External use only—do not ingest or use in the eyes

  • Use with caution in patients with:

    • Kidney disease (especially with large area application due to polyethylene glycol absorption)

    • Burns or open wounds

  • Discontinue if signs of local irritation, allergic reaction, or superinfection occur

  • Avoid prolonged use to prevent resistance development


🤒 Side Effects

Common:

  • Local burning or stinging

  • Itching

  • Redness or rash at application site

Rare/Serious:

  • Allergic dermatitis

  • Swelling of lips/face (hypersensitivity)

  • Secondary fungal infections with prolonged use

Seek medical help if severe irritation, rash, or allergic symptoms occur.


🔄 Drug Interactions

  • No significant systemic interactions

  • Avoid using other topical treatments at the same site unless directed


🧊 Storage Instructions

  • Store at 15–25°C

  • Keep tightly closed and away from heat or moisture

  • Do not freeze

  • Keep out of reach of children


📝 Conclusion

Mupirocin 2% is a safe, effective topical antibiotic ideal for treating localized skin infections and for eradicating nasal MRSA colonization. With broad action against key Gram-positive pathogens, it plays a vital role in infection control, wound care, and antibiotic stewardship when used responsibly under medical guidance.


Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult your healthcare provider for personalized recommendations.

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