TONACT ASP 20/150 CAPSULE

🧠💊 Atorvastatin 20mg + Aspirin 150mg Capsule: Dual Action for Heart and Vascular Protection

Atorvastatin 20mg + Aspirin 150mg capsule combines two powerful cardiovascular agents into one formulation, offering cholesterol-lowering and antiplatelet effects for effective prevention of heart attack, stroke, and other cardiovascular events. This fixed-dose combination is commonly prescribed to individuals at high risk of atherosclerosis-related complications, particularly those with coronary artery disease (CAD), hypertension, diabetes, or a history of myocardial infarction (MI) or stroke.

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🔬 Mechanism of Action

This capsule contains two drugs with complementary mechanisms:

🔹 Atorvastatin (20mg) – Statin (HMG-CoA reductase inhibitor)

• Inhibits the HMG-CoA reductase enzyme, reducing cholesterol synthesis in the liver

• Lowers LDL-C (bad cholesterol) and triglycerides

• Slightly increases HDL-C (good cholesterol)

• Stabilizes atherosclerotic plaques and reduces vascular inflammation

🔹 Aspirin (150mg) – Antiplatelet agent (NSAID)

• Irreversibly inhibits COX-1 enzyme in platelets

• Reduces thromboxane A2 production, preventing platelet aggregation

• Helps prevent blood clot formation in arteries

Together, they address two key aspects of cardiovascular disease: lipid buildup and blood clot formation.

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📌 Indications and Uses

This combination capsule is prescribed for:

• Secondary prevention of cardiovascular events in patients with:

  • Previous heart attack (MI)

  • Angina (chest pain)

  • Ischemic stroke or transient ischemic attack (TIA)

  • Post-coronary interventions (like stent placement or angioplasty)

• Primary prevention in high-risk individuals with:

  • Diabetes mellitus

  • Hypertension

  • Strong family history of heart disease

  • Dyslipidemia with multiple cardiovascular risk factors

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💊 Dosage and Administration

• Typical adult dose: One capsule once daily, usually in the evening (for better statin effect)

• Take with water, with or without food

• Do not crush or chew the capsule

Dosage may be adjusted based on lipid levels, platelet activity, and risk assessment.

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⚠️ Precautions and Warnings

• Atorvastatin-related cautions:

  • Monitor liver enzymes and lipid levels

  • Use caution in liver disease or alcohol abuse

• Aspirin-related cautions:

  • Avoid in active peptic ulcer, bleeding disorders, or asthma sensitive to NSAIDs

  • May increase bleeding risk, especially when combined with anticoagulants or alcohol

Use with caution in:

• Elderly patients

• Those with renal impairment

• Patients on anticoagulants or NSAIDs

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🤒 Side Effects

Common:

• Gastric irritation or heartburn

• Muscle aches (from statin)

• Headache or dizziness

• Easy bruising or minor bleeding (from aspirin)

Serious but rare:

• Rhabdomyolysis (severe muscle breakdown)

• Liver enzyme elevation

• GI bleeding or ulcers

• Allergic reactions

Seek immediate care for symptoms like dark urine, muscle weakness, black stools, or unusual bleeding.

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🔄 Drug Interactions

• Avoid with:

  • Other blood thinners (e.g., warfarin, heparin) without monitoring

  • Strong CYP3A4 inhibitors (e.g., clarithromycin, ketoconazole)

• Limit alcohol intake

• Inform doctor of all medications to prevent interactions

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🧊 Storage Instructions

• Store at 15–25°C, away from heat and moisture

• Keep out of reach of children

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📝 Conclusion

The Atorvastatin 20mg + Aspirin 150mg capsule offers a dual-action cardiovascular shield, lowering cholesterol and preventing blood clots to significantly reduce the risk of heart attacks, strokes, and other vascular events. With proven benefits and once-daily dosing, it’s an essential part of long-term therapy in individuals with or at high risk for cardiovascular disease—helping protect the heart and brain together.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.