VILDAMBIC-M 1000 TABLET

🩺🧪💊 Metformin 1000mg + Vildagliptin 50mg Tablet: A Dual-Action Therapy for Effective Type 2 Diabetes Control

Metformin 1000mg + Vildagliptin 50mg is a fixed-dose combination (FDC) oral antidiabetic medication used in the management of Type 2 Diabetes Mellitus (T2DM). This combination brings together two complementary agents:

• Metformin, a biguanide, which reduces blood glucose by decreasing liver glucose production and improving insulin sensitivity.

• Vildagliptin, a DPP-4 (Dipeptidyl Peptidase-4) inhibitor, which increases incretin hormones to stimulate insulin release and suppress glucagon.

Together, they provide comprehensive glycemic control with a low risk of hypoglycemia and no significant weight gain, making it suitable for long-term use in diabetic patients.

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🔬 Mechanism of Action

🔹 Metformin (1000mg)

• Decreases hepatic glucose output (gluconeogenesis)

• Enhances peripheral glucose uptake

• Improves insulin sensitivity

• Slows intestinal absorption of glucose

Metformin does not stimulate insulin secretion, thereby avoiding hypoglycemia in most cases.

🔹 Vildagliptin (50mg)

• Inhibits DPP-4 enzyme, increasing levels of GLP-1 and GIP

• Enhances glucose-dependent insulin secretion

• Suppresses glucagon release during hyperglycemia

• Helps maintain postprandial and fasting glucose levels

Vildagliptin works only when glucose levels are elevated, thus lowering the chance of hypoglycemia.

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📌 Indications and Uses

This combination is used in:

• Adults with Type 2 Diabetes not adequately controlled by metformin alone

• Patients who require dual therapy to achieve glycemic targets

• As an add-on to lifestyle modifications (diet and exercise)

• Suitable for overweight or obese patients due to weight-neutral profile

It may also delay the progression of diabetes-related complications such as neuropathy, nephropathy, and retinopathy when used as part of a comprehensive treatment plan.

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💊 Dosage and Administration

• Usual dosage: One tablet twice daily (morning and evening) with meals

• Swallow whole with water; do not crush or chew

• Dosage should be adjusted based on blood glucose levels and renal function

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⚠️ Precautions and Warnings

• Contraindicated in:

  • Renal impairment (eGFR < 30 mL/min/1.73m²)

  • Liver disease

  • Heart failure (unstable or recent)

  • Metabolic acidosis, including diabetic ketoacidosis

• Use with caution in:

  • Elderly patients

  • During surgery or radiological exams involving contrast dye (may temporarily discontinue)

• Avoid alcohol as it may increase the risk of lactic acidosis

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🤒 Side Effects

Common:

• Nausea

• Diarrhea

• Abdominal discomfort

• Headache

• Mild hypoglycemia (rare)

Rare/Serious:

• Lactic acidosis (a rare but serious complication of metformin)

• Pancreatitis

• Elevated liver enzymes (monitor during treatment)

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🔄 Drug Interactions

• Avoid with:

  • Alcohol

  • Diuretics and ACE inhibitors (monitor kidney function)

  • Cimetidine (may raise metformin levels)

• Generally safe with most commonly used diabetes, blood pressure, and cholesterol medicines

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🧊 Storage Instructions

• Store at 15–30°C, in a dry place

• Protect from light and moisture

• Keep out of reach of children

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📝 Conclusion

Metformin 1000mg + Vildagliptin 50mg is a convenient, effective, and well-tolerated combination therapy for adults with Type 2 Diabetes. By targeting both insulin resistance and glucose-dependent insulin secretion, it offers powerful and balanced blood sugar control with a low risk of side effects. Ideal for patients who need dual therapy in a single tablet, this combination helps maintain long-term glycemic goals and improves overall metabolic health.