NICIP ASP TABLET

💊 Aceclofenac 100mg + Paracetamol 325mg + Serratiopeptidase 15mg Tablet Overview

Introduction

This triple combination tablet is widely used to treat pain, inflammation, and swelling caused by conditions such as arthritis, sports injuries, post-surgical swelling, dental pain, or musculoskeletal disorders. It combines an NSAID, an analgesic-antipyretic, and a proteolytic enzyme for a synergistic effect.

---

🧪 Ingredients and Their Uses

• Aceclofenac (100mg): A non-steroidal anti-inflammatory drug (NSAID) that inhibits prostaglandins, reducing inflammation and pain.

• Paracetamol (325mg): Also known as acetaminophen, it enhances the analgesic effect and helps reduce fever.

• Serratiopeptidase (15mg): A proteolytic enzyme that reduces inflammation and swelling by breaking down abnormal proteins at the inflammation site. Commonly used post-surgery or injury for faster healing.

---

💡 How to Use

• Dosage: Typically 1 tablet twice daily, preferably after meals.

• Route: Oral. Swallow whole with water.

• Do not chew/crush. Prolonged use should only be under medical supervision.

---

🤕 Common Side Effects

Most are mild and transient:

• Nausea, vomiting

• Stomach discomfort, bloating

• Heartburn, indigestion

• Dizziness, drowsiness

• Mild diarrhea

Taking it with food reduces gastrointestinal symptoms.

---

⚠️ Serious Side Effects

Seek immediate medical attention if the following occur:

• Stomach bleeding or ulcers (vomiting blood, black stools)

• Liver damage (yellowing of skin/eyes, dark urine, fatigue)

• Kidney issues (reduced urination, swelling of feet/ankles)

• Allergic reactions (rash, facial swelling, difficulty breathing)

• Severe skin reactions like Stevens-Johnson syndrome (rare but serious)

Long-term or unsupervised use increases these risks.

---

🩺 Monitoring & Follow-Up

• Liver Function Tests (LFTs): Especially important due to paracetamol.

• Renal Function Tests (KFTs): NSAIDs may impair kidney function.

• Complete Blood Count (CBC): To detect any hidden gastrointestinal bleeding.

• Blood pressure monitoring: For those with heart conditions.

• Inflammatory markers (CRP/ESR): To track treatment effectiveness.

Regular follow-up is advised, especially in chronic users or elderly patients.

---

⚠️ Warnings & Precautions

• Alcohol: Avoid alcohol to reduce liver toxicity risk.

• Pregnancy & Breastfeeding: Use only when prescribed. Serratiopeptidase should be avoided during pregnancy.

• Elderly patients: Increased risk of GI bleeding and kidney impairment.

• Pre-existing conditions: Caution in liver, kidney, heart diseases, or stomach ulcers.

• Drug Interactions: Avoid with other NSAIDs, anticoagulants (warfarin), methotrexate, lithium, or certain antibiotics.

---

📌 Summary

Aceclofenac + Paracetamol + Serratiopeptidase is a potent combination for treating pain, swelling, and inflammation from various causes. Aceclofenac and paracetamol provide pain relief, while serratiopeptidase aids in faster healing by reducing tissue swelling. Though generally well-tolerated, the tablet should be used under medical supervision due to potential liver, kidney, and gastrointestinal side effects. Routine monitoring and adherence to dosage are essential for safe use.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.