PREGABID D 75/20 CAPSULE

🧠🔥💊 Duloxetine 20mg + Pregabalin 75mg Tablet: Dual-Action Relief for Nerve Pain, Anxiety & Fibromyalgia

The combination of Duloxetine 20mg and Pregabalin 75mg is a centrally acting medication used to treat neuropathic pain, generalized anxiety disorder (GAD), fibromyalgia, and chronic musculoskeletal pain. This fixed-dose formulation brings together two potent agents with complementary mechanisms of action, offering enhanced symptom relief in conditions involving nerve-related pain and mood disorders.

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🔬 Mechanism of Action

🔹 Duloxetine (20mg) – Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)

Duloxetine works by:

• Inhibiting the reuptake of serotonin and norepinephrine in the brain and spinal cord

• Modulating pain perception pathways

• Enhancing mood and reducing anxiety and depression

• Benefiting patients with both neuropathic pain and psychological symptoms

🔹 Pregabalin (75mg) – Alpha-2-delta Ligand / Anticonvulsant

Pregabalin:

• Binds to voltage-gated calcium channels in the central nervous system

• Reduces the release of pain-signaling neurotransmitters like glutamate, noradrenaline, and substance P

• Helps relieve nerve pain, burning, tingling, and seizure-related symptoms

• Also calms overactive nerves, helping with anxiety and sleep disturbances

Together, this combination targets both the sensory (pain) and emotional (mood) components of chronic conditions.

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📌 Indications and Uses

This combination is commonly prescribed for:

• Diabetic peripheral neuropathy

• Post-herpetic neuralgia

• Fibromyalgia

• Generalized anxiety disorder (GAD)

• Chronic low back pain or musculoskeletal pain

• Chemotherapy-induced neuropathic pain

• Sciatica and radiculopathy

• Mixed anxiety-depressive disorders with pain symptoms

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💊 Dosage and Administration

• Usual adult dose: One tablet once or twice daily, depending on medical advice

• Should be taken with or without food, at a fixed time each day

• Dose may be titrated based on tolerability and clinical response

• Swallow whole—do not crush or chew

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⚠️ Precautions and Warnings

• Use with caution in:

  • Liver or kidney impairment

  • History of seizures

  • Suicidal thoughts or depression

• Avoid sudden discontinuation—dose should be tapered gradually

• Not typically recommended for pregnant or breastfeeding women unless clearly needed

• Monitor for mood changes, dizziness, or sedation

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🤒 Side Effects

Common:

• Dizziness

• Sleepiness

• Dry mouth

• Nausea or constipation

• Blurred vision

• Increased appetite or weight gain

Serious but rare:

• Suicidal thoughts

• Liver enzyme elevation

• Serotonin syndrome (with other serotonergic agents)

• Allergic skin reactions

• Hyponatremia (low sodium)

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🔄 Drug Interactions

• Avoid alcohol or CNS depressants (increased sedation risk)

• Caution with:

  • MAO inhibitors, SSRIs, tramadol (risk of serotonin syndrome)

  • Antihypertensives or antiepileptics—adjust dose as needed

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🧊 Storage Instructions

• Store at 15–25°C, away from moisture and direct sunlight

• Keep in original packaging

• Keep out of reach of children

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📝 Conclusion

Duloxetine 20mg + Pregabalin 75mg provides dual-action relief by combining pain modulation and mood regulation in one tablet. It’s especially effective for patients with chronic nerve pain, fibromyalgia, or anxiety-pain syndromes, improving both physical and emotional well-being. With proper medical supervision, it can greatly enhance quality of life and daily functioning.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult your healthcare provider for personalized recommendations.