CADILOSE SOLUTION

🚽🌿💊 Lactulose 10gm/15ml Syrup: Gentle Relief from Constipation & Hepatic Encephalopathy

Lactulose 10gm/15ml is an osmotic laxative solution widely used for the treatment of chronic constipation and hepatic encephalopathy (a complication of liver disease). It is a synthetic disaccharide composed of galactose and fructose, designed to act locally in the colon without systemic absorption. Lactulose offers gentle, long-term bowel regulation and helps reduce toxic ammonia levels in liver-compromised patients.

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🔬 Mechanism of Action

Lactulose works via two main actions, depending on the condition being treated:

🌀 For Constipation:

• Lactulose reaches the colon unchanged (not absorbed in the small intestine)

• It is broken down by gut bacteria into low-molecular-weight acids (like lactic acid and acetic acid)

• These acids:

  • Increase water retention in the bowel (osmotic effect)

  • Soften stools

  • Stimulate intestinal peristalsis, promoting easier bowel movements

🧠 For Hepatic Encephalopathy:

• By acidifying the colon, Lactulose:

  • Converts ammonia (NH₃) into ammonium (NH₄⁺), which is less absorbable

  • Reduces blood ammonia levels

  • Suppresses urease-producing bacteria responsible for ammonia production

• This helps prevent or treat confusion, coma, and cognitive symptoms due to liver failure

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📌 Indications and Uses

Lactulose 10gm/15ml is used in:

✔️ Constipation:

• Chronic or occasional

• Especially helpful in elderly, post-operative, or opioid-induced constipation

✔️ Hepatic Encephalopathy:

• Prevention and treatment of episodes in cirrhotic patients

• Reduces risk of coma, disorientation, and mental status changes

It is considered safe for long-term use under medical supervision.

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💊 Dosage and Administration

For Constipation:

• Adults: Start with 15–45ml daily, adjusted to produce 2–3 soft stools per day

• Maintenance: 10–25ml once or twice daily

For Hepatic Encephalopathy:

• Initial: 30–50ml three times daily

• Adjust dose to achieve 2–3 soft stools per day

Administer orally. Can be mixed with water or juice for better taste. Takes 24–48 hours to show full effect.

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⚠️ Precautions and Warnings

• Avoid overuse, which may cause:

  • Electrolyte imbalance

  • Diarrhea and dehydration

• Use with caution in:

  • Diabetics (contains galactose and lactose)

  • Patients with galactosemia (contraindicated)

• Monitor fluid balance in elderly and renal-compromised patients

• Not for sudden, severe abdominal pain or suspected bowel obstruction

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🤒 Side Effects

Common:

• Bloating

• Flatulence

• Mild abdominal cramps

• Diarrhea (if overdosed)

Rare/Serious:

• Electrolyte disturbances (hypokalemia, hypernatremia)

• Dehydration with prolonged use

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🔄 Drug Interactions

• May reduce effectiveness of oral medications due to faster transit time

• Avoid co-administration with antacids, which may reduce its acidifying effect in hepatic encephalopathy

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🧊 Storage Instructions

• Store at room temperature (15–30°C)

• Protect from extreme heat or cold

• Do not freeze

• Keep tightly capped and out of reach of children

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📝 Conclusion

Lactulose 10gm/15ml syrup is a safe, effective, and well-tolerated solution for managing constipation and liver-related neurological complications. With its non-habit-forming nature, it is ideal for long-term therapy when used under guidance. Whether you need bowel regulation or ammonia control, Lactulose offers gentle relief with powerful results.