MISOPT EYE DROP

👁️💧🛡️ Dorzolamide 2% + Timolol 0.5% Eye Drops: Dual-Action Glaucoma Therapy

Dorzolamide 2% + Timolol 0.5% is a fixed-dose combination ophthalmic solution used to treat elevated intraocular pressure (IOP) in conditions like open-angle glaucoma and ocular hypertension. This powerful combo harnesses the benefits of two complementary drugs—Dorzolamide, a carbonic anhydrase inhibitor, and Timolol, a beta-blocker—to effectively lower eye pressure and prevent damage to the optic nerve, thereby reducing the risk of vision loss.

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🔬 Mechanism of Action

This eye drop provides a synergistic effect through two distinct pathways:

• Dorzolamide 2%: Inhibits carbonic anhydrase II in the ciliary body of the eye, which reduces the production of aqueous humor (fluid inside the eye).

• Timolol 0.5%: Blocks beta-adrenergic receptors in the eye, also decreasing aqueous humor production.

Together, these actions significantly reduce intraocular pressure, offering better control than either drug alone.

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📌 Indications and Uses

Indicated for the treatment of elevated intraocular pressure in patients with:

• Open-angle glaucoma

• Ocular hypertension

• Patients unresponsive to single-agent therapy

Also used when monotherapy with beta-blockers or carbonic anhydrase inhibitors is inadequate.

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💧 Dosage and Administration

• Recommended dose: One drop in the affected eye(s) twice daily

• Administer at regular intervals, usually 12 hours apart

• If using other eye medications, wait at least 10 minutes between applications

📝 Instructions for use:

1. Wash hands before and after use

2. Shake bottle gently

3. Avoid touching the dropper to any surface (including the eye)

4. Apply pressure to the inner corner of the eye (punctal occlusion) for 1-2 minutes to reduce systemic absorption

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⚠️ Precautions and Warnings

• Not for use in patients with asthma, severe COPD, or heart block/bradycardia

• Use with caution in patients with:

  • Kidney or liver impairment

  • History of sulfonamide allergy (Dorzolamide is a sulfonamide derivative)

• Monitor blood pressure and heart rate regularly

• Remove contact lenses before applying; wait 15 minutes before reinserting

🚫 Contraindications:

• Hypersensitivity to any component

• Cardiogenic shock or overt heart failure

• Severe reactive airway diseases

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🤒 Side Effects

Ocular:

• Burning or stinging sensation

• Blurred vision

• Eye redness or discomfort

• Dry eyes

Systemic (due to Timolol absorption):

• Fatigue

• Dizziness

• Low blood pressure or heart rate

• Shortness of breath (rare, serious)

Seek medical help if severe eye irritation, allergic reaction, or breathing difficulty occurs.

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🔄 Drug Interactions

• Avoid with:

  • Oral beta-blockers (risk of additive effects)

  • Calcium channel blockers, digoxin (increased risk of bradycardia)

  • Other carbonic anhydrase inhibitors (may increase systemic effects)

Monitor patients on multiple cardiovascular medications closely.

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🧊 Storage Instructions

• Store at 15–25°C, away from direct sunlight

• Keep the bottle tightly closed

• Discard 4 weeks after opening

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📝 Conclusion

Dorzolamide 2% + Timolol 0.5% eye drops offer a powerful, dual-mechanism therapy to lower intraocular pressure and prevent optic nerve damage in glaucoma and ocular hypertension. With convenient twice-daily dosing, this combination improves patient adherence and treatment outcomes. Regular monitoring and proper usage technique are key to maximizing its effectiveness while minimizing risks.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.