🩸💊 Dabigatran Etexilate 110mg Tablet: A Modern Oral Anticoagulant
Dabigatran Etexilate 110mg is an advanced oral anticoagulant (blood thinner) that helps prevent and treat the formation of harmful blood clots. It belongs to a class of medications called direct thrombin inhibitors and is commonly used for conditions such as non-valvular atrial fibrillation (NVAF), deep vein thrombosis (DVT), pulmonary embolism (PE), and post-surgical clot prevention. This medicine significantly reduces the risk of stroke, systemic embolism, and clot recurrence, offering an effective alternative to older anticoagulants like warfarin.
🔬 Mechanism of Action
Dabigatran is a prodrug, meaning it becomes active only after absorption in the body. It is converted to dabigatran, which directly inhibits thrombin (factor IIa) — a key enzyme in the blood coagulation cascade. By blocking thrombin, it prevents the transformation of fibrinogen into fibrin, which is essential for clot formation.
📌 Indications & Uses
Dabigatran 110mg is used in:
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Prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation
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Treatment of DVT and PE, and prevention of their recurrence
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Prevention of venous thromboembolism (VTE) after hip or knee replacement surgery
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Alternative to warfarin in patients who require consistent anticoagulation but want fewer dietary restrictions and no regular INR monitoring
💊 Dosage & Administration
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NVAF patients: 110mg twice daily, especially in elderly or those at higher bleeding risk
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DVT/PE treatment or prevention: Typically starts with parenteral anticoagulant for 5–10 days, then switched to Dabigatran 110mg or 150mg twice daily
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After orthopedic surgery: 110mg once on the first day, followed by 220mg daily
Take with a full glass of water, with or without food. Swallow capsules whole — do not crush or chew as this can increase bleeding risk.
⚠️ Precautions & Warnings
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Use cautiously in elderly, renal impairment, and those with a history of bleeding disorders
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Not recommended in mechanical heart valve patients
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Monitor for signs of gastrointestinal bleeding
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Requires discontinuation before surgery (usually 24–48 hours)
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A specific reversal agent (idarucizumab) is available for emergency bleeding
🤒 Side Effects
Common:
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Bleeding (nosebleeds, bruising, gum bleeding)
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Stomach discomfort
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Heartburn
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Nausea
Serious (seek immediate help):
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Unusual or prolonged bleeding
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Blood in urine or stools
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Severe headache or dizziness (possible brain bleed)
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Allergic reactions (rash, swelling, breathing difficulty)
🔄 Drug Interactions
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Increased bleeding risk with NSAIDs, antiplatelets, or other anticoagulants
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Interacts with P-glycoprotein inhibitors/inducers (e.g., amiodarone, verapamil, rifampin)
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Avoid alcohol and supplements that affect bleeding
🧊 Storage
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Store in original packaging to protect from moisture
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Keep at room temperature (15–30°C)
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Do not transfer to pill boxes
📝 Conclusion
Dabigatran Etexilate 110mg is a modern, effective, and convenient oral anticoagulant that plays a critical role in preventing strokes and clots. Its predictable action eliminates the need for frequent blood tests, offering patients freedom and safety—provided it is taken responsibly under medical supervision.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.
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