Description
💊 What is Dapagliflozin 10mg + Metformin 1000mg?
This is a fixed-dose combination medication used to manage Type 2 Diabetes Mellitus in adults. It combines:
- Dapagliflozin (10 mg) – an SGLT2 inhibitor
- Metformin (1000 mg) – a biguanide
This combination is often prescribed when blood sugar is not adequately controlled with metformin alone. It works through two complementary mechanisms to control blood glucose levels and help reduce the risk of diabetes-related complications.
✅ How to Use
- Dosage: Typically one tablet once or twice daily, depending on your doctor’s advice. The 1000 mg dose of Metformin is commonly divided into morning and evening doses to reduce stomach upset.
- Take with meals to minimize gastrointestinal side effects.
- Swallow whole with water — do not crush or split the tablet unless directed.
- Stay hydrated, especially when taking dapagliflozin.
- Follow diet and exercise plans alongside medication.
- Do not skip doses or stop without your doctor’s recommendation.
⚙️ How It Works
Component | Action | Benefit |
Dapagliflozin | Blocks glucose reabsorption in kidneys, causing sugar to be excreted in urine | Lowers blood sugar, may promote weight loss |
Metformin | Reduces liver glucose output and improves insulin sensitivity | Stabilizes blood sugar levels |
⚠️ Common Side Effects
System | Side Effects |
GI Tract | Nausea, diarrhea, abdominal pain (mostly due to Metformin) |
Urinary | Frequent urination, increased risk of urinary tract infections (from Dapagliflozin) |
General | Headache, fatigue, dizziness |
Others | Metallic taste, appetite loss |
🚨 Serious Side Effects (Rare but Important)
- Lactic Acidosis (Metformin-related): Look for muscle pain, weakness, breathing difficulty, or drowsiness. This is a medical emergency.
- Genital infections (e.g., yeast infections) from Dapagliflozin: due to increased glucose in urine.
- Ketoacidosis: Dapagliflozin can rarely cause this, even with normal blood sugar. Watch for nausea, vomiting, confusion, or shortness of breath.
- Kidney function decline: requires regular monitoring.
🧪 Monitoring During Treatment
Your doctor will monitor:
- Blood sugar (fasting/postprandial)
- HbA1c (every 3–6 months)
- Kidney function (creatinine, eGFR)
- Liver enzymes
- Signs of dehydration or infection
❗ Precautions
- Not for Type 1 Diabetes or diabetic ketoacidosis.
- Use caution if you have kidney, liver, or heart problems.
- Avoid alcohol – increases risk of lactic acidosis.
- Inform your doctor if you’re pregnant, breastfeeding, or planning surgery.
- Ensure adequate hydration, especially in hot weather or during illness.
📌 Summary
Dapagliflozin + Metformin is a powerful combination to control blood sugar in adults with Type 2 Diabetes. It works best when combined with healthy lifestyle changes. Monitor for side effects, stay hydrated, and attend regular medical checkups to ensure safe and effective treatment.
- For more detailed information, consult with your healthcare provider or refer to trusted medical resources.