🌿💊⚙️ Alfuzosin 10mg + Dutasteride 0.5mg Tablet: Dual Action Therapy for Enlarged Prostate (BPH)
Alfuzosin 10mg + Dutasteride 0.5mg is a combination medication used for the treatment of Benign Prostatic Hyperplasia (BPH), a non-cancerous enlargement of the prostate gland commonly seen in aging men. This combination helps in relieving urinary symptoms, reducing prostate size, and improving quality of life by targeting both the dynamic and static components of prostate enlargement.
🔬 Composition & Mechanism of Action
1. Alfuzosin (10mg) – Alpha-1 Blocker
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Relaxes the smooth muscle in the bladder neck and prostate.
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Improves urine flow and reduces symptoms like frequent urination, straining, and weak stream.
2. Dutasteride (0.5mg) – 5-Alpha Reductase Inhibitor
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Inhibits conversion of testosterone to dihydrotestosterone (DHT), a hormone responsible for prostate growth.
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Shrinks the prostate over time and prevents further enlargement.
Together, they offer immediate symptom relief (via alfuzosin) and long-term disease progression control (via dutasteride).
📌 Indications and Uses
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Treatment of moderate to severe BPH symptoms
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Prevention of acute urinary retention (AUR)
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Reduction in the need for prostate surgery
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Particularly beneficial in men with larger prostates
💊 Dosage and Administration
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Recommended dose: One tablet once daily, preferably after the same meal each day.
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Swallow whole with water—do not crush or chew.
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Dutasteride may take 3–6 months to show full effect; continued use is important.
⚠️ Precautions and Warnings
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Not for use in women or children
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Avoid handling broken tablets if pregnant (risk of fetal harm)
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Use with caution in:
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Liver impairment
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Severe kidney issues
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Low blood pressure (due to alfuzosin’s vasodilatory effect)
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⚠️ Dutasteride remains in the body for weeks – blood donation should be avoided for 6 months after stopping.
🤒 Side Effects
Common:
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Dizziness or low blood pressure (especially on standing)
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Decreased libido
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Erectile dysfunction
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Ejaculation problems
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Breast tenderness or enlargement
Rare/serious:
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Allergic reactions (rash, itching, swelling)
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Depression or mood changes
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Liver enzyme abnormalities
Seek medical help if any severe side effect occurs.
🔄 Drug Interactions
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Avoid with strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir) – may increase dutasteride levels.
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Caution with other blood pressure-lowering agents
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Not to be combined with other alpha-blockers
🧊 Storage Instructions
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Store at 15–30°C in a dry place.
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Protect from light and moisture
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Keep out of reach of children
📝 Conclusion
💡 Alfuzosin 10mg + Dutasteride 0.5mg provides a comprehensive approach to BPH management by combining immediate relief with long-term prostate reduction. It improves urinary symptoms, lowers the risk of complications, and enhances daily comfort for men suffering from prostate enlargement. With consistent use and proper monitoring, it can significantly improve urinary health and quality of life in aging males.
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