ACITROM 1.5 TABLET

🩸⚖️💊 Acenocoumarol 1.5mg Tablet: Precision Anticoagulation for Clot Prevention

Acenocoumarol 1.5mg is an oral anticoagulant (blood thinner) used to prevent and treat abnormal blood clots. It belongs to the class of Vitamin K antagonists (VKAs) and works by inhibiting clotting factor synthesis, making the blood less likely to form dangerous clots. It is commonly prescribed for patients at risk of deep vein thrombosis (DVT), pulmonary embolism (PE), or stroke, particularly in individuals with atrial fibrillation, mechanical heart valves, or a history of thromboembolic events.

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🔬 Mechanism of Action

Acenocoumarol works by inhibiting the enzyme vitamin K epoxide reductase, which is essential for the activation of vitamin K-dependent clotting factors (Factors II, VII, IX, and X). By blocking this pathway, acenocoumarol:

• Reduces blood clot formation

• Prevents existing clots from growing

• Maintains smoother blood flow in high-risk patients

Unlike direct-acting anticoagulants, acenocoumarol requires regular monitoring and dose adjustment based on blood tests.

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📌 Indications and Uses

Acenocoumarol 1.5mg is prescribed for:

• Prevention and treatment of deep vein thrombosis (DVT)

• Pulmonary embolism (PE)

• Prevention of stroke in atrial fibrillation (AF)

• Thromboprophylaxis in patients with mechanical heart valves

• Secondary prevention of myocardial infarction or embolic events

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💊 Dosage and Administration

• Dose is individualized based on INR (International Normalized Ratio) monitoring

• The usual maintenance dose ranges from 1mg to 8mg daily

• The goal INR range is typically 2.0–3.0, but may be higher (e.g., 2.5–3.5) for mechanical valve patients

• Taken orally once a day, preferably at the same time

Important: Dosing should never be changed without physician advice, and frequent INR checks are necessary to ensure safe and effective anticoagulation.

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⚠️ Precautions and Warnings

• Risk of bleeding is the most serious concern. Patients must be educated to report:

  • Unusual bruising or bleeding

  • Blood in urine or stools

  • Persistent headaches or dizziness

• Avoid in:

  • Pregnancy (Category X) – may cause fetal bleeding

  • Liver or kidney failure

  • Uncontrolled hypertension or bleeding disorders

Patients should carry an anticoagulant alert card or wear a medical ID for emergencies.

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🍲 Dietary Considerations

• Vitamin K-rich foods (e.g., spinach, kale, broccoli) can reduce effectiveness

• Maintain a consistent intake of such foods

• Avoid sudden dietary changes or herbal supplements (e.g., ginseng, St. John’s Wort)

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🤒 Side Effects

Common:

• Bleeding gums

• Easy bruising

• Nosebleeds

• Fatigue

Serious (seek immediate care):

• Blood in vomit, urine, or stool

• Severe headache (possible brain bleed)

• Skin necrosis (rare but serious)

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🔄 Drug Interactions

• Interacts with many medications, including:

  • Antibiotics

  • NSAIDs (e.g., ibuprofen)

  • Antiepileptics

  • Other anticoagulants

• Inform all healthcare providers before starting new medicines

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🧊 Storage Instructions

• Store at room temperature (15–25°C)

• Keep away from moisture and direct light

• Keep out of reach of children

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📝 Conclusion

Acenocoumarol 1.5mg is a potent and reliable anticoagulant used for the long-term prevention and treatment of blood clots. While highly effective, it requires strict INR monitoring, dietary consistency, and caution to avoid bleeding complications. With responsible use and medical supervision, acenocoumarol plays a critical role in protecting high-risk patients from potentially life-threatening thromboembolic events.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.