ACITROM 2.5 TABLET

🩸⚖️💊 Acenocoumarol 2.5mg Tablet: Precision Anticoagulation for Clot Prevention

Acenocoumarol 2.5mg is an oral anticoagulant (blood thinner) used to prevent and treat harmful blood clots. It belongs to the vitamin K antagonist (VKA) class, working similarly to warfarin, and is used to reduce the risk of stroke, deep vein thrombosis (DVT), pulmonary embolism (PE), and to manage atrial fibrillation or mechanical heart valves. Acenocoumarol is known for its shorter half-life compared to warfarin, which allows for easier dose adjustments in some patients.

🔬 Mechanism of Action

Acenocoumarol inhibits the enzyme vitamin K epoxide reductase, which is essential for the synthesis of clotting factors II, VII, IX, and X, and proteins C and S. By reducing the production of these vitamin K-dependent clotting factors in the liver, it prevents the formation and propagation of blood clots.

Key actions:

• Prevents new clots from forming

• Helps existing clots from growing larger

• Reduces the risk of embolic events, especially in heart-related conditions

📌 Indications and Uses

Acenocoumarol 2.5mg is prescribed for:

• Prevention and treatment of DVT and PE

• Prevention of stroke in patients with atrial fibrillation (AF)

• Anticoagulation in mechanical heart valve recipients

• Post-surgical thromboembolism prevention

• Hypercoagulable states (e.g., thrombophilia, antiphospholipid syndrome)

It is often prescribed long-term for patients at continued risk of thromboembolic events.

💊 Dosage and Administration

• Initial and maintenance doses vary per individual and must be tailored based on INR (International Normalized Ratio) levels.

• Starting dose: typically 1 to 4 mg daily, with adjustments as needed

• Target INR range:

  • 2.0–3.0 for most conditions (e.g., AF, DVT)

  • 2.5–3.5 for mechanical heart valves

Regular INR monitoring (usually every 2–4 weeks) is essential to ensure safety and efficacy.

Take at the same time daily, preferably in the evening, with or without food.

⚠️ Precautions and Warnings

• Bleeding risk increases with higher INR or improper dosing

• Monitor closely in:

  • Elderly

  • Liver or kidney disease

  • Recent surgery or trauma

  • Pregnancy (contraindicated)

• Interacts with many foods and drugs—patients must maintain a consistent vitamin K intake (green leafy vegetables)

Avoid:

• Alcohol

• Sudden dietary changes

• Invasive procedures without medical advice

🤒 Side Effects

Common:

• Minor bleeding (gum or nose bleeds, bruising)

• Gastrointestinal discomfort

Serious:

• Internal bleeding

• Hematuria (blood in urine)

• Black or tarry stools

• Hemorrhagic stroke (rare but life-threatening)

• Skin necrosis (very rare)

Seek immediate care for unusual bleeding, dizziness, or difficulty breathing.

🔄 Drug Interactions

• Increased effect: NSAIDs, antibiotics (e.g., erythromycin), antifungals

• Decreased effect: rifampicin, vitamin K, barbiturates

• Always inform healthcare providers about all current medications

🧊 Storage Instructions

• Store at room temperature (15–25°C)

• Protect from light and moisture

• Keep away from children and pets

📝 Conclusion

Acenocoumarol 2.5mg tablet is a lifesaving anticoagulant that requires careful monitoring and precision dosing. When used correctly, it effectively prevents dangerous blood clots and stroke, particularly in high-risk cardiovascular patients. Close collaboration with healthcare professionals and strict INR monitoring is key to safe and effective therapy.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.