ACITROM 3.5 TABLET

🩸⚖️💊 Acenocoumarol 3.5mg Tablet: Precision Anticoagulation for Thromboembolic Disorders

Acenocoumarol 3.5mg is an oral anticoagulant (blood thinner) used for the prevention and treatment of blood clots. It belongs to the class of vitamin K antagonists, working similarly to warfarin. This medication is commonly prescribed for conditions such as deep vein thrombosis (DVT), pulmonary embolism (PE), and to prevent stroke and systemic embolism in patients with atrial fibrillation or prosthetic heart valves.

By interfering with the production of clotting factors in the liver, Acenocoumarol helps maintain blood flow and reduces the risk of life-threatening clots, but it requires careful monitoring due to a narrow therapeutic window.

🔬 Mechanism of Action

Acenocoumarol inhibits the enzyme vitamin K epoxide reductase, thereby blocking the activation of vitamin K-dependent clotting factors II, VII, IX, and X. This interference leads to:

• Reduced clotting ability of blood

• Prevention of new clot formation

• Dissolution of existing small clots over time (indirectly)

The anticoagulant effect is not immediate; it generally takes 24–72 hours for full activity, depending on dosage and patient metabolism.

📌 Indications and Uses

Acenocoumarol 3.5mg is indicated for:

• Prevention and treatment of venous thromboembolism (VTE): DVT and PE

• Prevention of stroke in patients with atrial fibrillation

• Management of prosthetic heart valves

• Post-surgical thromboprophylaxis in orthopedic or cardiac patients

• Secondary prevention of myocardial infarction in selected patients

It is not used for acute treatment (e.g., acute PE)—initial anticoagulation is usually with heparin before transitioning to oral therapy.

💊 Dosage and Administration

• Dose is highly individualized based on INR (International Normalized Ratio) monitoring

• Usual initial dose: 2–4mg once daily, adjusted as per INR response

• Maintenance dose can range from 1mg to 10mg per day

• INR target:

  • 2.0–3.0 for most conditions (e.g., DVT, AF)

  • 2.5–3.5 for mechanical heart valves

Take at the same time daily, preferably in the evening. Do not skip or double doses. Monitor INR regularly.

⚠️ Precautions and Warnings

• Monitor INR frequently (especially during dose changes, illness, or when starting/stopping other medications)

• Avoid sudden changes in vitamin K intake (green leafy vegetables, etc.)

• Increased risk of bleeding in:

  • Elderly

  • Liver/kidney dysfunction

  • Concomitant use with antiplatelets or NSAIDs

• Contraindicated in pregnancy (risk of fetal harm)

• Caution in patients with peptic ulcers, recent surgery, or bleeding disorders

🤒 Side Effects

Common:

• Easy bruising

• Nosebleeds

• Bleeding gums

• Gastrointestinal discomfort

Serious (Seek immediate medical help):

• Blood in urine or stool

• Vomiting blood (coffee-ground appearance)

• Sudden severe headache (possible brain bleed)

• Heavy menstrual bleeding

🔄 Drug Interactions

• Potentiated by: antibiotics (e.g., ciprofloxacin), NSAIDs, alcohol

• Antagonized by: vitamin K-rich foods, rifampicin, barbiturates

• Many drug and food interactions—review all prescriptions and diet

🧊 Storage Instructions

• Store below 25°C, away from moisture and direct sunlight

• Keep out of reach of children

📝 Conclusion

Acenocoumarol 3.5mg is a potent oral anticoagulant vital for long-term thromboprophylaxis. While effective in reducing the risk of stroke and clot formation, it requires careful dose adjustment, INR monitoring, and dietary vigilance to ensure safety and efficacy. When managed properly, it offers life-saving protection for patients at risk of serious thromboembolic events.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.