ACT NVP TABLET

🤰💊🌿 Doxylamine 10mg + Pyridoxine Hydrochloride 10mg Tablet: Gentle Relief for Morning Sickness

The combination of Doxylamine 10mg and Pyridoxine Hydrochloride 10mg is a well-established and clinically approved treatment for nausea and vomiting in pregnancy (NVP), commonly referred to as morning sickness. This fixed-dose formulation is both effective and safe, especially during the first trimester, when these symptoms are most common and distressing.

It is often the first-line pharmacologic therapy recommended when dietary and lifestyle measures are not enough to manage symptoms of NVP.

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🔬 Mechanism of Action

This combination works synergistically to reduce nausea and vomiting through two different mechanisms:

🔹 Doxylamine (10mg)

• A first-generation antihistamine

• Blocks H1 histamine receptors in the brain, reducing nausea signals from the inner ear and gastrointestinal tract to the vomiting center

• Also has mild sedative effects, which can improve sleep and comfort during pregnancy

🔹 Pyridoxine (Vitamin B6) – 10mg

• Essential coenzyme in neurotransmitter metabolism

• Reduces nausea by normalizing central neurotransmitter activity, particularly involving serotonin and dopamine

• Safe and well-tolerated even in high doses

Together, these ingredients provide symptom relief without affecting the developing fetus.

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📌 Indications and Uses

This combination is primarily indicated for:

• Nausea and vomiting of pregnancy (NVP) – mild to moderate forms

• Particularly useful in first trimester where hormonal changes peak

• Adjunctive treatment in hyperemesis gravidarum (severe NVP), along with IV fluids and other medications

• Can also be used in non-pregnant patients for general nausea (off-label)

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💊 Dosage and Administration

• Typically started with 1 tablet at bedtime

• If symptoms persist, 1 tablet in the morning and 1 in the evening may be added

• Maximum dose: 4 tablets per day (1 morning, 1 afternoon, 2 at bedtime)

• Best taken on an empty stomach for optimal absorption

• Tablets should be swallowed whole, not chewed or crushed

Always follow dosing instructions provided by your healthcare provider, especially during pregnancy.

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⚠️ Precautions and Warnings

• Use only under medical supervision during pregnancy

• May cause drowsiness—avoid driving or operating machinery

• Avoid alcohol and other CNS depressants

• Not recommended in:

  • Patients with glaucoma

  • Asthma

  • Urinary retention

  • Severe liver impairment

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🤒 Side Effects

Common:

• Drowsiness or dizziness

• Dry mouth

• Headache

• Constipation

Less common but serious:

• Blurred vision

• Confusion (in older patients)

• Allergic reactions (rash, swelling, difficulty breathing)

Discontinue and seek medical attention if you experience severe side effects or allergic reactions.

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🔄 Drug Interactions

• Use cautiously with:

  • Antidepressants (may increase sedative effects)

  • Other antihistamines

  • Alcohol or sedatives

Always inform your doctor about all medications and supplements you are taking.

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🧊 Storage Instructions

• Store at room temperature (15–30°C)

• Protect from light and moisture

• Keep out of reach of children

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📝 Conclusion

The Doxylamine 10mg + Pyridoxine 10mg tablet offers safe, gentle, and effective relief from morning sickness, making it a trusted option for pregnant women experiencing nausea and vomiting. Its balanced formulation addresses both physical symptoms and sleep disturbances, ensuring improved quality of life during early pregnancy.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.