ADMENTA 10 TABLET

🧠🛡️💊 Memantine 10mg Tablet: Cognitive Support for Moderate to Severe Alzheimer’s Disease

Memantine 10mg is a centrally acting NMDA receptor antagonist used to treat moderate to severe Alzheimer’s disease (AD). It helps improve or stabilize cognitive function, memory, behavior, and daily living activities in patients suffering from progressive neurodegenerative disorders. Memantine works by regulating the brain’s glutamate activity, a neurotransmitter involved in learning and memory, which becomes dysregulated in Alzheimer’s disease.

Unlike other medications that increase acetylcholine (such as donepezil), Memantine offers a unique neuroprotective mechanism that complements cholinesterase inhibitors, and it can be used alone or in combination with them.

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🔬 Mechanism of Action

Memantine selectively blocks the N-methyl-D-aspartate (NMDA) receptor, which is excessively activated in Alzheimer’s patients due to high glutamate levels. This overstimulation leads to:

• Excitotoxicity (cell damage and death)

• Impaired synaptic plasticity

• Loss of cognitive function

By moderating glutamate activity, Memantine helps:

• Protect neurons from damage

• Preserve cognitive function

• Enhance communication between nerve cells

It does not cure Alzheimer’s but slows down symptom progression.

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📌 Indications and Uses

Memantine 10mg is indicated for:

• Moderate to severe Alzheimer’s disease

• Vascular dementia (off-label)

• Adjunct therapy with cholinesterase inhibitors like donepezil

• Other neurodegenerative diseases with cognitive decline (under investigation)

It is not approved for mild Alzheimer’s or age-related memory loss.

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💊 Dosage and Administration

• Starting dose: 5mg once daily

• Titrated up to 10mg twice daily (20mg/day) in divided doses

• Maintenance: 10mg once or twice daily, based on individual tolerance

• Dose adjustments required in renal impairment

Take with or without food. Swallow whole with water.

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⚠️ Precautions and Warnings

• Use with caution in:

  • Severe renal impairment (dose adjustment needed)

  • History of seizures

  • Cardiovascular conditions (e.g., uncontrolled hypertension)

• Not recommended for:

  • Mild Alzheimer’s

  • Pediatric use (not studied)

Caregivers should monitor for changes in mood, confusion, or worsening behavior.

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🤒 Side Effects

Common:

• Dizziness

• Headache

• Constipation

• Confusion (may be temporary)

• High blood pressure

Less common:

• Hallucinations

• Aggression or agitation

• Fatigue

• Sleep disturbances

Usually well tolerated. If side effects persist or worsen, consult a physician.

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🔄 Drug Interactions

• Use cautiously with:

  • Amantadine, ketamine, or dextromethorphan (similar mechanisms)

  • Carbonic anhydrase inhibitors and sodium bicarbonate (alter pH and affect excretion)

• No significant interaction with donepezil or other Alzheimer’s drugs

Always inform your doctor about all medications and supplements being used.

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🧊 Storage Instructions

• Store at 15–25°C (room temperature)

• Keep away from moisture and heat

• Out of reach of children and pets

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📝 Conclusion

Memantine 10mg offers effective symptom control in moderate to severe Alzheimer’s disease by protecting neurons from glutamate-induced damage. It helps improve mental clarity, communication, and daily living performance, often leading to better quality of life for both patients and caregivers. While not a cure, Memantine is a valuable component of long-term Alzheimer’s management.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.