Description
💼 PROSTATE RELIEF DUAL-ACTION TABLET 💼
Synergistic Therapy for Long-Term Management of BPH
💊 Composition (Per Capsule):
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Tamsulosin Hydrochloride (Modified Release) – 0.4 mg
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Dutasteride – 0.5 mg
🧠 Overview:
This fixed-dose combination of Tamsulosin and Dutasteride is designed for the long-term treatment of moderate to severe Benign Prostatic Hyperplasia (BPH) in men with an enlarged prostate. Tamsulosin provides fast symptom relief, while Dutasteride shrinks prostate volume and helps prevent disease progression, including the risk of acute urinary retention or surgical intervention. Together, they offer a comprehensive, dual-mechanism approach to BPH management.
🔬 Mechanism of Action:
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Tamsulosin 0.4 mg:
A selective alpha-1A adrenergic receptor antagonist that relaxes smooth muscle in the prostate, bladder neck, and urethra, improving urine flow and alleviating Lower Urinary Tract Symptoms (LUTS) like frequency, urgency, and weak stream. -
Dutasteride 0.5 mg:
A dual 5-alpha-reductase inhibitor that blocks the conversion of testosterone to dihydrotestosterone (DHT), the primary hormone responsible for prostate growth. By reducing DHT, Dutasteride shrinks the prostate, relieves obstruction, and lowers the risk of urinary retention or surgery.
🎯 Indications:
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Moderate to severe Benign Prostatic Hyperplasia (BPH)
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LUTS associated with prostate enlargement
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Prevention of BPH complications such as urinary retention or prostate surgery
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Suitable for men with prostate volume >30 mL
✅ Therapeutic Benefits:
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Rapid symptom relief from Tamsulosin within days
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Prostate size reduction with Dutasteride over 3–6 months
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Reduces post-void residual urine and nocturia
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Lowers need for catheterization or prostate surgery
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Improves urinary flow and patient quality of life
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Suitable for chronic management of BPH
💊 Dosage & Administration:
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Adults (Males ≥18 years):
1 capsule once daily, ideally 30 minutes after the same meal each day -
The capsule should be swallowed whole, not chewed or crushed
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Minimum duration of therapy: 6 months for full benefit from Dutasteride
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Regular follow-up is essential to monitor efficacy and side effects
⚠️ Precautions & Side Effects:
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Common Side Effects:
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Decreased libido
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Ejaculation disorders
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Erectile dysfunction
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Dizziness or orthostatic hypotension
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Breast tenderness or enlargement
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Rare but Serious:
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Depression or mood changes
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High-grade prostate cancer risk (controversial, Dutasteride-related)
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Intraoperative Floppy Iris Syndrome during cataract surgery
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Contraindications:
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Women and children (Dutasteride is teratogenic)
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Severe hepatic impairment
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Caution in patients with cardiovascular disorders or low blood pressure
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🧪 Monitoring Guidelines:
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Monitor PSA levels regularly (Dutasteride reduces PSA by ~50%)
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Evaluate urinary symptoms using the IPSS (International Prostate Symptom Score)
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Routine prostate exams and digital rectal examination (DRE) recommended
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Monitor for sexual dysfunction or mood changes in long-term use
🛡️ Storage Instructions:
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Store at 15–25°C, away from light and moisture
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Keep out of reach of children and pregnant women
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Capsules should not be handled by women of childbearing age
📝 Conclusion:
The Tamsulosin + Dutasteride combination is a powerful, long-term solution for BPH that tackles both symptoms and structural progression. With complementary actions, this dual therapy improves urinary function, reduces complications, and enhances quality of life for men with enlarged prostate and LUTS.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.
