ALPHAGAN P EYE DROP

👁️💧🛡️ Brimonidine 0.15% + Stabilized Oxychloro 0.005% Eye Drops: Precision Control for Intraocular Pressure

Brimonidine 0.15% + Stabilized Oxychloro 0.005% is a prescription ophthalmic solution used in the management of ocular hypertension and open-angle glaucoma. This combination brings together the intraocular pressure (IOP)-lowering action of Brimonidine, an alpha-2 adrenergic receptor agonist, with Stabilized Oxychloro Complex (SOC), which acts as a gentle preservative ensuring prolonged shelf life and improved ocular safety compared to traditional preservatives like benzalkonium chloride.

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🔬 Mechanism of Action

Brimonidine Tartrate 0.15%

Brimonidine works by reducing aqueous humor production and increasing uveoscleral outflow, leading to a decrease in intraocular pressure. This is essential in slowing or preventing optic nerve damage associated with glaucoma.

• Onset of action: within 1 hour

• Peak effect: at 2–3 hours

• Duration: up to 12 hours

Stabilized Oxychloro Complex 0.005% (Purite®)

SOC acts as a mild oxidative preservative, which:

• Maintains antimicrobial protection of the eye drops

• Breaks down into harmless substances like water and salt upon contact with light

• Minimizes preservative-induced irritation and allergic responses

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📌 Indications and Therapeutic Use

This ophthalmic solution is used for:

• Primary open-angle glaucoma

• Ocular hypertension

• As an adjunctive therapy when IOP is not controlled with a single agent

Its dual-action in IOP control and enhanced tolerability makes it ideal for long-term use in patients requiring chronic eye pressure management.

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💧 Dosage and Administration

• Recommended dose: 1 drop in the affected eye(s) twice daily (every 12 hours)

• Avoid touching the dropper tip to any surface

• Wait at least 5 minutes before using other ophthalmic medications

• Remove contact lenses before instillation and wait 15 minutes before reinserting

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⚠️ Precautions and Warnings

• Use with caution in patients with:

  • Severe cardiovascular disease

  • Depression

  • Orthostatic hypotension

  • Hepatic or renal impairment

• Not recommended for children under 2 years of age

• Can cause drowsiness or fatigue—caution advised during activities requiring alertness

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🤒 Possible Side Effects

Common:

• Eye redness or dryness

• Blurred vision

• Foreign body sensation

• Mild burning or stinging on application

Less Common but Serious:

• Allergic conjunctivitis

• Fatigue or drowsiness

• Decreased blood pressure or heart rate (rare)

• Eye inflammation or lid swelling

Discontinue use and consult an eye specialist if severe symptoms occur.

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🔄 Drug Interactions

• May interact with:

  • CNS depressants (enhanced sedative effect)

  • Monoamine oxidase inhibitors (risk of hypertensive crisis)

• Always inform your doctor about other medications or eye drops in use

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🧊 Storage Instructions

• Store at 15–25°C in a cool, dry place

• Protect from light and avoid contamination

• Discard 4 weeks after opening the bottle

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📝 Conclusion

Brimonidine 0.15% + Stabilized Oxychloro 0.005% eye drops offer an effective, well-tolerated, and patient-friendly solution for controlling intraocular pressure in glaucoma and ocular hypertension. The combination ensures therapeutic efficacy with reduced risk of preservative-related irritation, making it suitable for long-term ocular care.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.