Name: ALSITA GM 1 FORTE TABLET
Brand: Alkem Laboratories Ltd
SKU: 17528
Availability: InStock

Description

Sitagliptin 50mg + Glimepiride 1mg + Metformin 1000mg is a triple-drug oral antidiabetic combination used in the management of Type 2 Diabetes Mellitus (T2DM). It is typically prescribed for patients whose blood glucose levels are not adequately controlled by dual therapy alone.

This formulation combines three complementary agents:

Sitagliptin (50mg): A DPP-4 inhibitor that enhances the activity of incretin hormones, increasing insulin release and decreasing glucagon secretion in response to meals.
Glimepiride (1mg): A sulfonylurea that stimulates pancreatic beta cells to secrete more insulin, helping to reduce fasting blood glucose levels.
Metformin (1000mg): A biguanide that lowers hepatic glucose production, improves insulin sensitivity, and reduces intestinal glucose absorption.

Together, these medications work synergistically to address insulin resistance, inadequate insulin secretion, and excess hepatic glucose production, making the combination highly effective for glycemic control.

Safety Advice

1. Hypoglycemia Risk (Glimepiride):
Due to the sulfonylurea component, this combination carries a risk of low blood sugar (hypoglycemia). Symptoms include shakiness, sweating, confusion, dizziness, or hunger. Always keep a quick source of glucose (like sugar or candy) on hand.

2. Lactic Acidosis Warning (Metformin):
Though rare, lactic acidosis is a serious side effect of metformin, particularly in patients with kidney or liver impairment, alcohol use, dehydration, or major illness. Signs include deep breathing, nausea, weakness, or abdominal pain. Seek urgent medical attention if suspected.

3. Risk of Pancreatitis (Sitagliptin):
There have been rare reports of acute pancreatitis associated with sitagliptin. Severe abdominal pain, especially if radiating to the back, should be evaluated promptly.

4. Kidney and Liver Function Monitoring:
Routine renal and hepatic function tests are necessary during treatment, as all three drugs can affect or be influenced by organ function. Dose adjustments may be required based on kidney function.

5. Alcohol Caution:
Avoid excessive alcohol intake, which may raise the risk of both lactic acidosis and hypoglycemia.

6. Not for Type 1 Diabetes or DKA:
This medication is intended only for Type 2 Diabetes Mellitus. It is not suitable for Type 1 Diabetes or Diabetic Ketoacidosis (DKA).

Storage Instructions

Store at 15–30°C (59–86°F).
Keep the medication in a cool, dry place, protected from moisture and light.
Keep in original packaging until use.
Do not refrigerate unless instructed by a pharmacist.
Keep out of reach of children and pets.

Additional Notes

Administration: Usually taken once daily with food, preferably breakfast or the first major meal, to reduce stomach upset and minimize the risk of hypoglycemia.
Missed Dose: Take as soon as remembered. If it’s nearly time for the next dose, skip the missed one. Never double the dose.
Lifestyle Modifications: Best results occur when combined with a balanced diet, physical activity, and weight control.
Routine Monitoring: Regular checks of blood glucose, HbA1c, kidney function, and overall metabolic status are essential.
Inform Your Doctor: Disclose all medications, including OTC and herbal supplements, to avoid drug interactions.

Conclusion

Sitagliptin 50mg + Glimepiride 1mg + Metformin 1000mg is a potent triple-action therapy for patients with uncontrolled Type 2 Diabetes. It combines insulin sensitization, secretion enhancement, and hormonal regulation. When used correctly, under medical supervision and with lifestyle changes, it significantly improves blood sugar control and helps prevent complications.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.