Description
Description
Sitagliptin 50mg + Metformin 1000mg is an oral combination medication used to manage Type 2 Diabetes Mellitus (T2DM) in adults. It combines two complementary agents that help lower blood sugar levels:
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Sitagliptin: A Dipeptidyl Peptidase-4 (DPP-4) inhibitor that increases levels of incretin hormones. These hormones increase insulin release and decrease glucagon levels in a glucose-dependent manner, especially after meals.
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Metformin: A biguanide that works by decreasing hepatic glucose production, improving insulin sensitivity, and reducing intestinal glucose absorption.
This combination is usually prescribed when diet, exercise, and metformin alone do not provide adequate glycemic control. It may also be used as part of a broader treatment plan involving other antidiabetic medications.
Safety Advice
1. Risk of Lactic Acidosis (Metformin)
Metformin, although generally safe, carries a rare but serious risk of lactic acidosis, especially in people with kidney impairment, liver disease, or dehydration. Symptoms include muscle pain, fatigue, breathing difficulty, and abdominal discomfort. Seek immediate medical attention if these occur.
2. Kidney Function Monitoring
Renal function should be assessed before starting the drug and monitored regularly during treatment. Dose adjustments or discontinuation may be necessary in case of reduced kidney function.
3. Low Risk of Hypoglycemia
Sitagliptin does not cause low blood sugar by itself. However, when combined with other medications like insulin or sulfonylureas, the risk of hypoglycemia may increase. Be cautious and monitor blood glucose levels closely.
4. Pancreatitis Warning
There is a potential risk of pancreatitis associated with DPP-4 inhibitors like sitagliptin. Sudden, severe abdominal pain (with or without vomiting) should be reported immediately to a healthcare provider.
5. Avoid Excessive Alcohol Consumption
Alcohol can increase the risk of lactic acidosis with metformin. It is advisable to limit or avoid alcohol during treatment.
6. Not for Type 1 Diabetes or DKA
This medication is not suitable for Type 1 Diabetes or for treating diabetic ketoacidosis (DKA).
Storage Instructions
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Store at room temperature (15–30°C or 59–86°F).
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Keep away from direct sunlight, heat, and moisture.
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Store the medicine in its original container to protect it from external factors.
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Keep out of reach of children and pets.
Additional Notes
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Take With Food: To reduce gastrointestinal side effects, take this medicine with meals, preferably after food.
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Missed Dose: If you forget a dose, take it as soon as you remember. If it’s close to your next dose, skip the missed one—do not double the dose.
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Weight-Neutral: This combination is generally weight-neutral, making it suitable for patients concerned about weight gain.
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Lifestyle is Key: For best results, this medication should be combined with a balanced diet, regular physical activity, and weight control.
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Drug Interactions: Inform your doctor of all medications you are taking, including OTC products and supplements, to avoid interactions.
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Pregnancy and Lactation: Use in pregnancy or breastfeeding should only occur if clearly needed and under medical advice.
Conclusion:
Sitagliptin 50mg + Metformin 1000mg is an effective and well-tolerated combination therapy for managing Type 2 diabetes. With proper monitoring and adherence to safety guidelines, it can help maintain long-term glycemic control and improve quality of life.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.
