AMADAY 10 TABLET

Amlodipine 10 mg is a widely prescribed medication belonging to the class of drugs known as calcium channel blockers (CCBs). It is primarily used to treat high blood pressure (hypertension) and chronic stable angina (chest pain). Amlodipine works by relaxing the blood vessels, which allows blood to flow more easily, thereby reducing the heart’s workload and lowering blood pressure.

🩺 Mechanism of Action

Amlodipine inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle cells. By blocking calcium channels, it prevents calcium from entering cells of the heart and blood vessel walls, leading to vasodilation (widening of blood vessels). This helps to lower blood pressure and reduce the frequency and severity of angina episodes. Unlike some other antihypertensive agents, Amlodipine has minimal effects on heart rate and cardiac output.

✅ Uses and Indications

• Hypertension (High Blood Pressure):
  Amlodipine helps lower elevated blood pressure, reducing the risk of stroke, heart attack, and kidney problems.

• Chronic Stable Angina:
  It prevents chest pain caused by reduced blood flow to the heart muscle.

• Vasospastic Angina (Prinzmetal’s Angina):
  It is effective in relieving chest pain due to coronary artery spasms.

• Coronary Artery Disease:
  In patients with coronary artery disease but no heart failure, Amlodipine can reduce hospitalizations and symptoms.

💊 Dosage and Administration

• The typical starting dose for adults is 5 mg once daily, which may be increased to 10 mg once daily depending on the patient’s response.

• It can be taken with or without food.

• Amlodipine has a long half-life (30–50 hours), allowing for once-daily dosing.

⚠️ Side Effects

While Amlodipine is generally well-tolerated, some patients may experience side effects, especially when starting the medication or increasing the dose:

• Common Side Effects:

  • Swelling of the ankles or feet (edema)

  • Headache

  • Dizziness or lightheadedness

  • Flushing

  • Fatigue

• Less Common/Serious Side Effects:

  • Irregular heartbeat

  • Chest pain (new or worsened)

  • Shortness of breath

  • Severe allergic reactions (rare)

⚠️ Precautions and Warnings

• Liver Impairment:
  Patients with liver problems may require dose adjustments, as Amlodipine is metabolized in the liver.

• Heart Conditions:
  Use cautiously in patients with severe aortic stenosis or heart failure.

• Pregnancy and Breastfeeding:
  Should only be used if clearly needed. Safety during pregnancy is not fully established.

• Driving and Machinery:
  Dizziness may impair the ability to perform tasks requiring alertness.