AMANTEX TABLET

💊 AMANTADINE 100 mg CAPSULE

Dual-Action Agent for Neurology & Antiviral Therapy

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COMPOSITION:

• Amantadine Hydrochloride 100 mg
  (Oral capsule or tablet formulation)

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WHAT IS AMANTADINE 100 mg?

Amantadine 100 mg is a multifunctional medication primarily used in the management of Parkinson’s disease and drug-induced extrapyramidal symptoms. It also has antiviral properties, particularly against influenza A virus. Amantadine acts on the central nervous system (CNS) and viral replication mechanisms, offering unique dual therapeutic applications.

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MECHANISM OF ACTION:

Amantadine works through two main pathways:

1. Neurological Effects:

   • Enhances the release of dopamine from presynaptic terminals.

   • Blocks NMDA (N-methyl-D-aspartate) receptors, modulating glutamate transmission.

   • Reduces Parkinsonian symptoms such as tremor, rigidity, and bradykinesia.

2. Antiviral Action:

   • Inhibits the M2 protein of the influenza A virus.

   • Prevents viral uncoating, halting replication within host cells.

   • Has limited use today due to widespread resistance among influenza A strains.

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INDICATIONS:

• Parkinson’s disease (monotherapy or adjunct to levodopa)

• Drug-induced extrapyramidal symptoms (e.g., from antipsychotic medications)

• Prophylaxis and treatment of influenza A (when susceptible strains are confirmed)

• Fatigue in multiple sclerosis (off-label use in some settings)

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DOSAGE & ADMINISTRATION:

• Neurological indications:

  • Adults: 100 mg once or twice daily (max 200 mg/day)

  • Dose adjusted based on age, renal function, and tolerability

• Antiviral use:

  • Adults: 100 mg twice daily for 5–7 days

  • Elderly or renal impairment: Reduce to 100 mg once daily

Take with or without food. Swallow capsule/tablet whole with water.

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KEY BENEFITS:

✅ Dual action: neurological and antiviral
✅ Reduces Parkinson’s symptoms and drug-induced tremors
✅ Useful as adjunct therapy in early Parkinson’s disease
✅ Can help manage fatigue in neurological conditions (off-label)

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PRECAUTIONS:

• Use caution in patients with:

  • Seizure disorders

  • Congestive heart failure

  • Liver or kidney impairment

  • History of psychiatric illness

• Dose must be adjusted in elderly and those with renal impairment

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POSSIBLE SIDE EFFECTS:

• Common: Dizziness, dry mouth, nausea, insomnia, anxiety

• Occasional: Livedo reticularis (mottled skin discoloration), edema

• Rare: Hallucinations, confusion, agitation, urinary retention, orthostatic hypotension

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CONTRAINDICATIONS:

• Known hypersensitivity to amantadine

• Untreated angle-closure glaucoma

• Severe renal impairment (without dose adjustment)

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STORAGE INSTRUCTIONS:

• Store at room temperature (15–30°C)

• Protect from light and moisture

• Keep out of reach of children

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DISCLAIMER:

This summary is for educational purposes only. Always consult a qualified healthcare provider before starting or discontinuing any medication. Amantadine requires medical supervision, especially in neurological or elderly patients.