Description
💊 AMANTADINE 193 mg EXTENDED-RELEASE CAPSULE
Targeted Neurological Therapy with 24-Hour Symptom Control
COMPOSITION:
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Amantadine Hydrochloride 193 mg
(Extended-release capsule for oral administration, once daily)
WHAT IS AMANTADINE 193 mg?
Amantadine 193 mg extended-release is a dopaminergic agent and NMDA receptor antagonist used to treat specific symptoms in Parkinson’s disease (PD) and drug-induced extrapyramidal reactions. This dosage form delivers sustained symptom relief with a single daily dose, improving compliance and reducing fluctuation in drug levels.
It is especially effective for Parkinson’s disease-related dyskinesia, making it a valuable adjunct to levodopa therapy in advanced-stage PD.
MECHANISM OF ACTION:
Amantadine acts via dual central mechanisms:
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Dopaminergic Modulation
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Increases dopamine release and inhibits dopamine reuptake in the brain.
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Alleviates symptoms such as rigidity, tremors, and bradykinesia in Parkinson’s disease.
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NMDA Receptor Antagonism
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Inhibits N-methyl-D-aspartate (NMDA) receptors, reducing glutamatergic overactivity.
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Helps manage levodopa-induced dyskinesia by regulating excitatory neurotransmission.
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INDICATIONS:
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Parkinson’s disease (as monotherapy in early stages or adjunct in advanced PD)
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Treatment of levodopa-induced dyskinesia
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Drug-induced extrapyramidal symptoms (EPS), especially from antipsychotics
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Fatigue in multiple sclerosis (off-label)
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Post-viral fatigue syndromes (investigational use)
DOSAGE & ADMINISTRATION:
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Usual adult dose:
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193 mg once daily, preferably in the morning
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May be titrated depending on clinical response and tolerability
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Swallow capsule whole—do not crush, chew, or open
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Renal function should be assessed before initiating treatment
KEY BENEFITS:
✅ Once-daily dosing for patient convenience
✅ Controls both Parkinsonian symptoms and dyskinesia
✅ Extended-release profile ensures stable drug levels
✅ Can reduce need for higher levodopa doses
✅ May improve motor function, fatigue, and daily activity
PRECAUTIONS:
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Caution in patients with:
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Renal impairment
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History of seizures
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Congestive heart failure
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Psychiatric disorders (hallucinations, confusion)
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Avoid sudden discontinuation—taper gradually
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May cause sleep disturbances if taken too late in the day
POSSIBLE SIDE EFFECTS:
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Common: Dry mouth, dizziness, insomnia, constipation, nausea
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Occasional: Orthostatic hypotension, anxiety, blurred vision
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Rare:
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Livedo reticularis (mottled skin discoloration)
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Hallucinations or confusion in elderly
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Peripheral edema
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CONTRAINDICATIONS:
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Hypersensitivity to amantadine
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Untreated narrow-angle glaucoma
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Severe renal dysfunction (without dose adjustment)
STORAGE CONDITIONS:
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Store at 15–30°C, protected from light and moisture
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Keep in original container and out of reach of children
DISCLAIMER:
This summary is intended for informational and educational purposes only. Always consult a qualified healthcare provider before starting or stopping any medication. Proper monitoring is essential for safe use, especially in elderly or renally impaired patients.
