Description
💊 AMANTADINE 100 mg CAPSULE
Dual-Action Agent for Neurology & Antiviral Therapy
COMPOSITION:
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Amantadine Hydrochloride 100 mg
(Oral capsule or tablet formulation)
WHAT IS AMANTADINE 100 mg?
Amantadine 100 mg is a multifunctional medication primarily used in the management of Parkinson’s disease and drug-induced extrapyramidal symptoms. It also has antiviral properties, particularly against influenza A virus. Amantadine acts on the central nervous system (CNS) and viral replication mechanisms, offering unique dual therapeutic applications.
MECHANISM OF ACTION:
Amantadine works through two main pathways:
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Neurological Effects:
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Enhances the release of dopamine from presynaptic terminals.
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Blocks NMDA (N-methyl-D-aspartate) receptors, modulating glutamate transmission.
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Reduces Parkinsonian symptoms such as tremor, rigidity, and bradykinesia.
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Antiviral Action:
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Inhibits the M2 protein of the influenza A virus.
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Prevents viral uncoating, halting replication within host cells.
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Has limited use today due to widespread resistance among influenza A strains.
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INDICATIONS:
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Parkinson’s disease (monotherapy or adjunct to levodopa)
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Drug-induced extrapyramidal symptoms (e.g., from antipsychotic medications)
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Prophylaxis and treatment of influenza A (when susceptible strains are confirmed)
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Fatigue in multiple sclerosis (off-label use in some settings)
DOSAGE & ADMINISTRATION:
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Neurological indications:
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Adults: 100 mg once or twice daily (max 200 mg/day)
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Dose adjusted based on age, renal function, and tolerability
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Antiviral use:
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Adults: 100 mg twice daily for 5–7 days
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Elderly or renal impairment: Reduce to 100 mg once daily
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Take with or without food. Swallow capsule/tablet whole with water.
KEY BENEFITS:
✅ Dual action: neurological and antiviral
✅ Reduces Parkinson’s symptoms and drug-induced tremors
✅ Useful as adjunct therapy in early Parkinson’s disease
✅ Can help manage fatigue in neurological conditions (off-label)
PRECAUTIONS:
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Use caution in patients with:
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Seizure disorders
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Congestive heart failure
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Liver or kidney impairment
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History of psychiatric illness
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Dose must be adjusted in elderly and those with renal impairment
POSSIBLE SIDE EFFECTS:
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Common: Dizziness, dry mouth, nausea, insomnia, anxiety
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Occasional: Livedo reticularis (mottled skin discoloration), edema
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Rare: Hallucinations, confusion, agitation, urinary retention, orthostatic hypotension
CONTRAINDICATIONS:
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Known hypersensitivity to amantadine
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Untreated angle-closure glaucoma
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Severe renal impairment (without dose adjustment)
STORAGE INSTRUCTIONS:
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Store at room temperature (15–30°C)
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Protect from light and moisture
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Keep out of reach of children
DISCLAIMER:
This summary is for educational purposes only. Always consult a qualified healthcare provider before starting or discontinuing any medication. Amantadine requires medical supervision, especially in neurological or elderly patients.
