💊 Ampicillin 125mg + Cloxacillin 125mg Tablet
(Dual Penicillin Antibiotic for Broad & Resistant Infections)
🧪 What Is It?
Ampicillin + Cloxacillin is a combination antibiotic used to treat a range of bacterial infections, particularly those caused by Gram-positive and Gram-negative bacteria, including resistant strains that produce beta-lactamase.
Common indications include:
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Respiratory tract infections
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Skin and soft tissue infections
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ENT infections (e.g. tonsillitis, otitis media)
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Urinary tract infections
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Bone and joint infections
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Dental infections
🔬 Ingredients & Mechanism of Action
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Ampicillin (125mg): A broad-spectrum penicillin antibiotic effective against both Gram-positive and some Gram-negative bacteria. It works by inhibiting bacterial cell wall synthesis, leading to cell death.
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Cloxacillin (125mg): A beta-lactamase-resistant penicillin, particularly effective against penicillinase-producing Staphylococcus aureus. It also disrupts bacterial cell wall synthesis but resists destruction by bacterial enzymes.
Together, they broaden antibacterial coverage and help overcome resistance.
💡 How to Use
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Typical Dosage: 1 tablet every 6 or 8 hours, depending on severity and doctor’s instructions.
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Route: Oral.
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Administration: Best taken on an empty stomach (1 hour before or 2 hours after meals) for better absorption. Swallow whole with water.
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Duration: Complete the full course even if symptoms improve early to prevent resistance.
🤕 Common Side Effects
Generally mild and self-limiting:
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Nausea or vomiting
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Diarrhea or loose stools
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Abdominal cramps
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Mild skin rash or itching
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Metallic taste or dry mouth
⚠️ Serious Side Effects (Seek Immediate Medical Attention)
Rare but may include:
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Severe allergic reactions (anaphylaxis): Swelling, breathing difficulty, hives
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Stevens-Johnson Syndrome or toxic epidermal necrolysis (very rare)
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Clostridium difficile-associated diarrhea: Severe, persistent diarrhea
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Liver toxicity: Jaundice, dark urine, fatigue
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Seizures (rare): In very high doses or patients with kidney impairment
🩺 Monitoring & Follow-Up
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Kidney Function Tests (KFTs): Especially in long-term use or renally impaired patients
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Liver Function Tests (LFTs): Monitor in patients on prolonged therapy
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Watch for superinfections or fungal overgrowth with long-term use
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Allergy screening: Especially if prior beta-lactam allergy is suspected
⚠️ Warnings & Precautions
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Penicillin Allergy: Avoid if there’s a known allergy to penicillins or cephalosporins.
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Renal Impairment: Dose adjustment may be necessary.
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Pregnancy & Lactation: Generally considered safe, but should be prescribed by a physician.
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Drug Interactions: May reduce the effect of oral contraceptives and interact with methotrexate or anticoagulants.
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Food Interaction: Best absorbed on an empty stomach.
📌 Summary
Ampicillin 125mg + Cloxacillin 125mg is a dual-action antibiotic designed to treat a broad range of bacterial infections, especially those caused by resistant staphylococcal strains. Ampicillin offers broad-spectrum coverage, while cloxacillin resists beta-lactamase enzymes. It is usually well-tolerated and effective when taken as prescribed, but attention must be given to allergic reactions, kidney/liver function, and full course completion to prevent resistance.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.
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