AZMARDA 100 TABLET

❤️💊 Sacubitril 49mg + Valsartan 51mg Tablet: A Powerful Mid-Dose ARNI for Heart Failure Relief

Sacubitril 49mg + Valsartan 51mg is a mid-strength Angiotensin Receptor–Neprilysin Inhibitor (ARNI) tablet used to treat patients with heart failure with reduced ejection fraction (HFrEF). This dual-acting medication offers superior benefits over conventional therapies like ACE inhibitors or ARBs alone by targeting both the neurohormonal and natriuretic peptide pathways. It is commonly used as the intermediate dose in a stepped treatment approach before reaching the full therapeutic dose.

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🔬 Mechanism of Action

This combination brings together two potent components:

• Sacubitril (49mg): A neprilysin inhibitor that blocks the enzyme neprilysin, responsible for breaking down beneficial natriuretic peptides (like ANP and BNP). These peptides promote:

  • Vasodilation

  • Natriuresis (sodium excretion)

  • Diuresis (fluid elimination)

  • Reduction in cardiac remodeling

• Valsartan (51mg): An angiotensin II receptor blocker (ARB) that prevents angiotensin II from binding to its receptor. This leads to:

  • Vasodilation

  • Reduced blood pressure

  • Decreased aldosterone secretion

  • Less cardiac strain and fibrosis

Combined, they work synergistically to improve cardiac output, reduce hospitalizations, and enhance survival in heart failure patients.

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📌 Indications and Uses

Sacubitril 49mg + Valsartan 51mg is indicated for:

• Chronic heart failure (HFrEF) in adults with ejection fraction ≤ 40%

• Patients who remain symptomatic despite standard heart failure therapy

• Individuals already stabilized on the lower dose (24/26mg) and are ready for dose escalation

This mid-dose is a stepping stone toward the full dose (97/103mg), allowing the body to adjust gradually to the blood pressure-lowering effects.

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💊 Dosage and Administration

• Typically prescribed as one tablet twice daily

• Usually initiated after 2–4 weeks of tolerating the 24/26mg dose

• Can be taken with or without food

• Requires a 36-hour washout period after discontinuing any ACE inhibitor to avoid angioedema

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⚠️ Precautions and Warnings

• Monitor blood pressure, serum potassium, and renal function regularly

• Contraindicated in:

  • History of angioedema

  • Use with ACE inhibitors or aliskiren

  • Pregnancy and breastfeeding

• Caution in:

  • Severe hepatic or renal impairment

  • Low baseline blood pressure

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🤒 Side Effects

Common side effects:

• Dizziness or fatigue

• Low blood pressure (hypotension)

• Elevated potassium levels (hyperkalemia)

• Renal function deterioration

Serious but rare:

• Angioedema (swelling of face, lips, throat)

• Severe hypotension or syncope

• Acute kidney injury

Report any signs of swelling, difficulty breathing, or fainting immediately.

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🔄 Drug Interactions

• Do not combine with:

  • ACE inhibitors (requires 36-hour gap)

  • Aliskiren (especially in diabetics)

  • Potassium-sparing diuretics or supplements (risk of hyperkalemia)

• Caution with NSAIDs, lithium, and diuretics

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🧊 Storage Guidelines

• Store at 15–30°C, in a dry place

• Protect from light and moisture

• Keep out of reach of children

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📝 Conclusion

Sacubitril 49mg + Valsartan 51mg is a vital mid-step dose in ARNI-based heart failure therapy. It provides powerful cardiovascular protection, improves symptoms, and reduces hospitalization and mortality. When used with proper monitoring and dose progression, it transforms the standard of care in chronic heart failure management.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.