BACTOCLAV DS 457 SYRUP

🌟 AMOXYCILLIN 400mg/5ml + CLAVULANIC ACID 57mg/5ml SYRUP: HIGH-STRENGTH ANTIBIOTIC FOR TOUGH INFECTIONS 🌟

Amoxycillin 400mg/5ml + Clavulanic Acid 57mg/5ml syrup is a high-potency oral antibiotic suspension designed primarily for children over 3 months of age. This combination offers enhanced action against a broad spectrum of bacterial pathogens, especially those resistant to standard antibiotics. The formulation is often prescribed in moderate to severe pediatric infections, where a stronger dose is necessary for effective bacterial eradication.

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🔬 Composition and Mechanism of Action

• Amoxycillin (400mg per 5ml): A broad-spectrum beta-lactam antibiotic from the penicillin group that disrupts bacterial cell wall synthesis, leading to cell death.

• Clavulanic Acid (57mg per 5ml): A beta-lactamase inhibitor that prevents bacterial enzymes from breaking down amoxycillin, thereby restoring and extending its antibacterial activity.

This potent combination targets both beta-lactamase-producing and non-resistant bacteria, making it suitable for treating a wide range of infections, especially when resistance is a concern.

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💊 Indications and Therapeutic Uses

This high-strength formulation is typically used for:

• Recurrent or persistent ear infections (otitis media)

• Acute bacterial sinusitis

• Lower respiratory tract infections (e.g., bronchitis, community-acquired pneumonia)

• Urinary tract infections (UTIs)

• Skin and soft tissue infections

• Dental infections in children

It is often chosen in cases where standard amoxicillin or lower-dose combinations have failed or where more aggressive bacterial strains are suspected.

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⚠️ Precautions and Contraindications

Precautions:

• Always administer with food to improve absorption and minimize gastrointestinal discomfort.

• Shake well before each use for uniform dosing.

• Use strictly as per weight-based dosing instructions from a pediatrician.

• Complete the entire prescribed course, even if symptoms resolve early.

Contraindications:

• Allergy to penicillins, cephalosporins, or clavulanic acid.

• History of cholestatic jaundice or liver dysfunction linked to previous amoxicillin/clavulanate use.

Special caution should be taken in children with renal impairment, gastrointestinal diseases, or a history of drug allergies.

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🚨 Possible Side Effects

Though generally safe, some children may experience side effects, including:

• Common: Diarrhea, nausea, vomiting, diaper rash, abdominal discomfort

• Moderate: Oral thrush (candidiasis), mild skin rashes

• Serious (Rare): Anaphylactic reaction, liver enzyme abnormalities, Stevens-Johnson syndrome, antibiotic-associated colitis

Hydration and close observation are essential, especially in cases of persistent diarrhea or allergic reactions.

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🧊 Storage and Handling

• Once reconstituted, store the syrup in a refrigerator (2°C–8°C).

• Discard any unused syrup after 7–10 days.

• Keep away from direct sunlight and out of reach of children.

• Do not freeze.

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📋 Important Notes

• Use only under medical supervision.

• Overuse or inappropriate use can lead to antibiotic resistance.

• Dosing accuracy is crucial—use the measuring device provided.

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Amoxycillin 400mg + Clavulanic Acid 57mg per 5ml syrup is a powerful and reliable choice in pediatric infectious disease management, particularly when standard therapy is insufficient. With correct use, it provides rapid symptom relief, bacterial clearance, and reduced risk of complications—ensuring a swift return to health for your child.