BRIVGARD 100 TABLET

🧠⚡💊 Brivaracetam 100mg Tablet: Advanced Therapy for Seizure Control

Brivaracetam 100mg is an antiepileptic medication (AED) used primarily for the treatment of partial-onset seizures in adults and adolescents aged 16 years and older. It is a newer generation drug structurally related to levetiracetam but with higher affinity and more targeted action. Brivaracetam provides enhanced seizure control with fewer behavioral side effects in some patients, making it a preferred choice in epilepsy management.

---

🔬 Mechanism of Action

Brivaracetam works by binding selectively and with high affinity to synaptic vesicle protein 2A (SV2A), a protein involved in the release of neurotransmitters at synapses. By modulating this protein, brivaracetam stabilizes neuronal activity, reducing hyperexcitability in the brain and helping to prevent the onset and spread of seizures.

Its high selectivity results in:

• Faster onset of action

• Better seizure suppression

• Fewer mood-related adverse effects compared to some older AEDs

---

📌 Indications and Therapeutic Uses

Brivaracetam 100mg is primarily indicated for:

• Partial-onset seizures (with or without secondary generalization)

• Used as monotherapy or adjunctive therapy alongside other anticonvulsants

It is typically prescribed when patients have not achieved adequate seizure control with first-line therapies, or in those experiencing side effects from older AEDs.

---

💊 Dosage and Administration

• Standard adult dose: 50mg to 100mg twice daily (total daily dose of 100–200mg)

• May be taken with or without food

• Dose adjustments may be needed for:

  • Hepatic impairment

  • Renal impairment (though brivaracetam is mainly metabolized in the liver)

It is essential to follow a consistent dosing schedule and not abruptly discontinue the medication, as this may trigger seizures.

---

⚠️ Precautions and Warnings

• Use with caution in patients with a history of:

  • Depression, suicidal thoughts, or psychiatric illness

  • Severe liver disease

• Monitor for signs of mood changes, aggression, anxiety, or suicidal ideation

• Avoid alcohol as it can potentiate CNS side effects

---

🤒 Common Side Effects

Brivaracetam is generally well-tolerated. Common side effects may include:

• Drowsiness or fatigue

• Dizziness or lightheadedness

• Nausea

• Headache

• Irritability or mood changes

• Ataxia (unsteady movement)

Rare but serious side effects:

• Hypersensitivity or allergic reactions

• Aggressive behavior or suicidal thoughts

• Liver enzyme elevations (monitor liver function in long-term use)

Seek immediate medical attention if experiencing severe rash, difficulty breathing, or abnormal behavior.

---

🔄 Drug Interactions

• May interact with:

  • Levetiracetam (avoid concurrent use due to similar mechanism)

  • Carbamazepine, phenytoin: may alter brivaracetam levels

  • Rifampin (reduces brivaracetam levels)

• Caution with CNS depressants (e.g., opioids, alcohol) due to additive sedation

---

🧊 Storage Instructions

• Store below 25°C, away from moisture and heat

• Keep out of reach of children

---

📝 Conclusion

Brivaracetam 100mg offers a modern, effective solution for patients with partial-onset epilepsy, either alone or with other medications. With rapid brain penetration, high SV2A binding affinity, and a generally favorable side effect profile, it is a valuable option in seizure management. Patient adherence and regular follow-up are key to ensuring optimal control and minimizing risks.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.