Description
Ibuprofen 400 mg + Paracetamol 325 mg Tablet
Effective Dual-Action Pain Relief and Fever Reduction
Overview
The combination of Ibuprofen 400 mg and Paracetamol (Acetaminophen) 325 mg offers synergistic relief from pain and fever. This medication is commonly used to treat conditions such as headache, toothache, musculoskeletal pain, backache, menstrual cramps, arthritis, and fever. Together, they provide faster onset and longer duration of action compared to either drug alone.
Ingredients and Their Roles
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Ibuprofen (400 mg):
A non-steroidal anti-inflammatory drug (NSAID) that works by blocking prostaglandins, substances in the body that cause inflammation, pain, and fever. It reduces swelling and provides anti-inflammatory benefits. -
Paracetamol (325 mg):
An analgesic and antipyretic that works primarily in the central nervous system to reduce pain and lower fever. Unlike ibuprofen, it does not have significant anti-inflammatory effects, making it gentler on the stomach.
How to Use
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Dosage: As directed by your physician, typically 1 tablet every 6–8 hours if needed.
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Maximum Daily Dose: Do not exceed 3 tablets in 24 hours unless advised.
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Route: Oral, with food or milk to prevent stomach upset.
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Hydration: Drink plenty of water while using this medication.
Common Side Effects
These side effects are generally mild and transient:
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Nausea or upset stomach
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Heartburn or indigestion
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Drowsiness or dizziness
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Mild rash
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Headache
Serious Side Effects (Seek immediate medical attention)
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Allergic reaction: skin rash, itching, swelling (especially of face/tongue), severe dizziness, difficulty breathing
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Gastrointestinal bleeding: black or bloody stools, vomiting blood
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Liver damage (due to Paracetamol): yellowing of skin or eyes, dark urine, persistent nausea
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Kidney problems: reduced urine output, swelling in legs
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Increased blood pressure or chest pain (rare)
Monitoring & Follow-Up
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Short-Term Use: Usually does not require extensive monitoring if used as directed.
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Long-Term Use: Requires monitoring of:
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Liver function tests (due to Paracetamol)
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Kidney function (due to Ibuprofen)
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Blood pressure in hypertensive patients
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Clinical Review: Recommended if used more than 7–10 consecutive days.
Warnings & Precautions
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Liver Disease: Use with caution; Paracetamol is hepatotoxic at high doses.
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Kidney Disease: Ibuprofen may worsen renal function.
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Heart Disease or High Blood Pressure: Ibuprofen may increase cardiovascular risks.
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Stomach Ulcers or GI Bleeding History: Avoid prolonged use.
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Alcohol: Avoid excessive alcohol, especially with Paracetamol—may increase liver toxicity.
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Pregnancy & Breastfeeding: Use only if clearly needed under medical supervision.
Summary
The Ibuprofen + Paracetamol combination tablet delivers fast and effective relief from various types of pain and fever through two complementary mechanisms. It is widely used for both acute and short-term conditions, offering enhanced pain control without the need for opioids. However, it should be used cautiously in people with liver, kidney, or gastrointestinal issues, and not beyond the recommended duration or dosage. Always follow your healthcare provider’s advice for safe and effective use.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult your healthcare provider for personalized recommendations.
