🧪💉 Ceftriaxone 1000mg + Sulbactam 500mg + Disodium Edetate 37mg Injection: Triple Power Antibiotic for Tough Infections

🔬 Overview:

This potent triple-combination injectable antibiotic is used to combat serious bacterial infections in both hospital and clinical settings. It blends a third-generation cephalosporin (Ceftriaxone), a beta-lactamase inhibitor (Sulbactam), and a stabilizer/chelating agent (Disodium Edetate) to enhance efficacy, safety, and drug stability.

🧪 Composition:

• Ceftriaxone Sodium – 1000mg (1g): A broad-spectrum cephalosporin antibiotic that interferes with bacterial cell wall synthesis.

• Sulbactam Sodium – 500mg: A beta-lactamase inhibitor that prevents bacterial enzymes from deactivating ceftriaxone.

• Disodium Edetate (EDTA) – 37mg: A chelating agent that binds metal ions, improving the stability of ceftriaxone and preventing degradation.

Formulation Type: Lyophilized powder for reconstitution
Route of Administration: Intravenous (IV) or Intramuscular (IM) under strict medical supervision

⚕️ Uses & Indications:

This triple-drug injection is used in the treatment of moderate to severe bacterial infections, such as:

• Respiratory tract infections (e.g., community-acquired pneumonia)

• Intra-abdominal infections

• Skin and soft tissue infections

• Urinary tract infections (UTIs)

• Meningitis

• Bone and joint infections

• Surgical site and gynecological infections

• Sepsis and bloodstream infections

Not effective for viral infections such as the flu or COVID-19.

⚖️ Mechanism of Action:

• Ceftriaxone: Disrupts bacterial cell wall synthesis.

• Sulbactam: Inhibits bacterial beta-lactamases, extending ceftriaxone’s activity.

• Disodium Edetate: Enhances shelf life and prevents degradation by chelating calcium/magnesium ions.

❗ Possible Side Effects:

Common side effects may include:

• Pain or swelling at injection site

• Rash, itching, or mild allergic reactions

• Nausea, diarrhea, or abdominal discomfort

• Elevated liver enzymes

• Headache or dizziness

Rare but serious effects:

• Anaphylaxis (severe allergic reaction)

• Hemolytic anemia or blood disorders

• Superinfections (e.g., fungal overgrowth)

⚠️ Precautions:

• Allergies: Contraindicated in patients allergic to cephalosporins or penicillins.

• Renal/Hepatic Impairment: Requires dose adjustment and monitoring.

• Pregnancy/Lactation: Use only when clearly needed, under medical advice.

• Drug Interactions: Avoid combining with calcium-containing IV fluids or nephrotoxic agents.

• Pediatric Use: Safe in children with weight-based dosing.

📦 Storage Guidelines:

• Store the vial below 25°C, away from light and moisture.

• Reconstituted solution should be used within the prescribed time frame (often within 6 hours if not refrigerated).

• Keep out of reach of children.

📝 Conclusion:

Ceftriaxone 1000mg + Sulbactam 500mg + Disodium Edetate 37mg injection offers a comprehensive, triple-action approach against resistant and hard-to-treat infections. The inclusion of EDTA enhances drug stability, making it a reliable and advanced choice for critical care settings. However, use must be judicious and physician-guided to prevent adverse reactions and antibiotic resistance.