CILACAR NB 5 TABLET

❤️NEBIVOLOL 5MG + CILNIDIPINE 10MG – ADVANCED DUAL-ACTION CONTROL FOR MODERN HYPERTENSION

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✅ OVERVIEW:

Nebivolol 5mg + Cilnidipine 10mg is a fixed-dose combination antihypertensive medication that offers dual cardiovascular protection. It combines:

• Nebivolol (5mg) – a highly selective beta-1 adrenergic receptor blocker with nitric oxide–mediated vasodilation, improving vascular function and reducing heart rate.

• Cilnidipine (10mg) – a calcium channel blocker that acts on both L-type and N-type calcium channels, leading to smooth muscle relaxation and reduced sympathetic nerve activity.

Together, they offer complementary mechanisms to achieve better blood pressure control with minimal metabolic impact, making this combination especially useful in high-risk or treatment-resistant hypertension.

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🩺 USES:

1. Primary Hypertension:
   Effective first-line or add-on therapy in patients with moderate to severe high blood pressure.

2. Hypertension with Tachycardia:
   Nebivolol reduces heart rate, while Cilnidipine controls vascular resistance without causing reflex tachycardia.

3. Hypertension with Metabolic Syndrome or Diabetes:
   This combination has a neutral or beneficial effect on lipid and glucose metabolism.

4. Resistant Hypertension:
   Useful in patients not responding adequately to monotherapy.

5. Elderly Hypertensives or Those with Arterial Stiffness:
   Improves endothelial function and arterial compliance.

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🧪 INGREDIENTS:

• Active Ingredients:

  • Nebivolol Hydrochloride equivalent to 5mg Nebivolol

  • Cilnidipine 10mg

• Inactive Ingredients: (May vary by brand)

  • Microcrystalline cellulose

  • Magnesium stearate

  • Lactose monohydrate

  • Povidone

  • Film-coating polymers (e.g., hypromellose, titanium dioxide)

Usually presented as a film-coated tablet, designed for once-daily dosing.

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⚠️ SIDE EFFECTS:

Common:

• Dizziness, fatigue, or lightheadedness

• Headache

• Slow heart rate (bradycardia)

• Mild peripheral edema (swelling in feet or ankles)

Less Common but Serious:

• Severe hypotension (low blood pressure)

• Depression or sleep disturbances

• Allergic reactions

• Worsening of asthma or bronchospasm (rare with cardioselective beta-blockers)

• Bradyarrhythmias

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⚠️ PRECAUTIONS:

• Bradycardia: Not suitable for patients with resting heart rates below 60 bpm.

• Heart Failure: Use cautiously; avoid in unstable heart failure.

• Asthma/COPD: Though Nebivolol is cardioselective, beta-blockers may still pose risks in bronchospastic conditions.

• Kidney or Liver Impairment: Dose adjustments may be needed.

• Pregnancy & Lactation: Not recommended unless clearly indicated.

• Avoid Abrupt Discontinuation: May cause rebound hypertension or angina.

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🕒 DOSAGE & ADMINISTRATION:

• Usually taken once daily, at the same time each day.

• Can be taken with or without food.

• Swallow whole; do not crush or split the tablet.

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🔁 STORAGE:

• Store in a cool, dry place (20–25°C / 68–77°F).

• Protect from direct sunlight and moisture.

• Keep away from children.

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🩺 SUMMARY:

Nebivolol 5mg + Cilnidipine 10mg is a modern and well-tolerated option for patients with hypertension, especially those needing heart rate control and vascular relaxation in one pill. It offers cardiovascular safety, minimal metabolic interference, and is ideal for long-term blood pressure management in diverse patient populations.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.