CILAHEART TC 12.5 TABLET

💊 Telmisartan 40mg + Cilnidipine 10mg + Chlorthalidone 12.5mg Tablet

Triple Action Power for Complete Hypertension Management

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Introduction:

Telmisartan 40mg + Cilnidipine 10mg + Chlorthalidone 12.5mg is a fixed-dose triple combination antihypertensive formulated to provide comprehensive blood pressure control in patients with moderate to severe hypertension. This all-in-one therapy targets multiple pathways—vascular resistance, fluid retention, and sympathetic overactivity—offering a synergistic and long-lasting effect.

This triple therapy is particularly beneficial for patients who are inadequately controlled with dual therapy and require maximum efficacy with once-daily dosing.

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Pharmacological Action:

1. Telmisartan 40mg – An angiotensin II receptor blocker (ARB) that:

   • Prevents vasoconstriction by blocking angiotensin II receptors

   • Reduces aldosterone levels, decreasing sodium and water retention

   • Offers cardiovascular and renal protection, especially in diabetic patients

2. Cilnidipine 10mg – A dual L/N-type calcium channel blocker that:

   • Inhibits L-type calcium channels causing vasodilation

   • Blocks N-type channels, reducing sympathetic nerve activity

   • Minimizes reflex tachycardia and protects renal function

3. Chlorthalidone 12.5mg – A long-acting thiazide-like diuretic that:

   • Promotes excretion of sodium and water

   • Reduces plasma volume and peripheral resistance

   • Has a prolonged duration of action (up to 72 hours) for sustained BP control

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Therapeutic Uses:

• Moderate to severe essential hypertension

• Resistant hypertension (uncontrolled with dual therapy)

• Hypertension with diabetes, obesity, or chronic kidney disease (CKD)

• Patients with high cardiovascular risk

• Suitable for step-up therapy or those needing multi-pathway BP control

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Dosage and Administration:

• One tablet once daily, preferably in the morning

• May be taken with or without food

• Should be swallowed whole with water

• Regular monitoring of blood pressure, electrolytes, and renal function is advised

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Key Benefits:

• Triple mechanism for enhanced BP control

• Once-daily dosage ensures 24-hour efficacy and improved compliance

• Reduces risk of cardiovascular events like stroke and heart attack

• Renal protective effects, especially beneficial in diabetics

• Controls morning BP surge—a major trigger for cardiovascular events

• Limits side effects seen with high doses of individual drugs

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Common Side Effects:

• Dizziness or lightheadedness

• Fatigue or weakness

• Increased urination

• Ankle swelling (rare with Cilnidipine compared to other CCBs)

• Muscle cramps

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Serious but Rare Side Effects:

• Electrolyte disturbances (low potassium, sodium)

• Hypotension or fainting, especially in volume-depleted patients

• Worsening renal function in at-risk populations

• Allergic reactions or rash

• Hyperuricemia or elevated blood glucose (from diuretic)

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Precautions:

• Not recommended during pregnancy or breastfeeding

• Monitor in patients with renal or hepatic impairment

• Avoid combining with other potassium-sparing agents or supplements

• Alcohol may enhance hypotensive effect

• Periodic monitoring of electrolytes, uric acid, and kidney function is essential

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Storage:

• Store at 15–30°C in a cool, dry place

• Keep away from direct sunlight and moisture

• Out of reach of children

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Conclusion:

Telmisartan + Cilnidipine + Chlorthalidone offers a powerful, well-tolerated, and convenient triple therapy for difficult-to-control hypertension. It delivers multifaceted protection for the heart, kidneys, and arteries—making it an ideal choice for long-term cardiovascular risk reduction and better quality of life.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.