Description
💊 Amoxycillin 500mg + Clavulanic Acid 125mg Tablet
(Broad-Spectrum Antibiotic with Beta-Lactamase Inhibitor)
🧪 What Is It?
This combination tablet contains two active ingredients used to treat a wide range of bacterial infections:
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Respiratory tract infections (e.g. sinusitis, bronchitis, pneumonia)
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Urinary tract infections (UTIs)
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Skin and soft tissue infections
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Dental infections
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Bone and joint infections
It is not effective against viral infections like the common cold or flu.
🔬 Ingredients & Mechanism of Action
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Amoxycillin (500 mg): A broad-spectrum penicillin antibiotic that kills bacteria by inhibiting bacterial cell wall synthesis.
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Clavulanic Acid (125 mg): A beta-lactamase inhibitor that prevents resistant bacteria from inactivating amoxycillin. It enhances the effectiveness of amoxycillin against resistant strains.
Together, they form a synergistic combination to combat a wider range of bacterial infections.
💡 How to Use
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Usual Dosage: 1 tablet every 8 or 12 hours, as directed by the physician.
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Route: Oral.
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Administration: Take with or just after food to reduce stomach upset. Swallow whole with water.
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Course Duration: Complete the full course, even if symptoms improve early.
🤕 Common Side Effects
These are typically mild and temporary:
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Diarrhea or loose stools
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Nausea, vomiting
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Abdominal discomfort
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Skin rash or itching
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Headache
Taking the tablet with meals may help reduce gastrointestinal symptoms.
⚠️ Serious Side Effects (Seek Immediate Medical Attention)
Rare but potentially dangerous reactions include:
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Severe allergic reactions: Hives, swelling of the face/lips/tongue, breathing difficulty
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Clostridium difficile-associated diarrhea (CDAD): Persistent watery or bloody diarrhea
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Liver toxicity: Yellowing of the skin/eyes (jaundice), dark urine
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Seizures: In patients with kidney issues or very high doses
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Severe skin reactions: Such as Stevens-Johnson syndrome
🩺 Monitoring & Follow-Up
Monitoring is typically needed in long-term therapy or in special patient groups:
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Liver Function Tests (LFTs): Prolonged use may affect liver enzymes.
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Renal Function Tests (KFTs): Especially in elderly or renal-impaired patients.
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CBC (Complete Blood Count): For detecting allergic or hematologic responses.
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Watch for antibiotic-associated diarrhea or superinfections.
⚠️ Warnings & Precautions
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Allergy: Avoid in patients allergic to penicillins or cephalosporins.
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Liver or Kidney Disease: Use with caution; dose adjustment may be needed.
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Pregnancy & Lactation: Generally safe but should be used under medical supervision.
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Alcohol: Not contraindicated, but alcohol may worsen side effects like nausea.
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Drug Interactions: May interfere with oral contraceptives or interact with methotrexate and allopurinol.
📌 Summary
Amoxycillin 500mg + Clavulanic Acid 125mg Tablet is a powerful broad-spectrum antibiotic used to treat various bacterial infections, especially those caused by beta-lactamase-producing resistant organisms. Amoxycillin attacks bacterial cell walls, while clavulanic acid blocks resistance mechanisms, making the antibiotic more effective. It is generally well-tolerated, but monitoring is essential in patients with kidney or liver issues. Proper adherence to dosage and duration is key to treatment success and resistance prevention.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.
