CLOMILENT 25 TABLET

🧠💊 Clomipramine 25mg Tablet: An Essential Antidepressant & OCD Treatment

Clomipramine 25mg is a tricyclic antidepressant (TCA) primarily used to treat obsessive-compulsive disorder (OCD), as well as depression, panic attacks, and certain anxiety disorders. It acts on brain chemicals to help restore mental balance and reduce intrusive thoughts, compulsions, and mood disturbances.

🔬 Mechanism of Action

Clomipramine works by inhibiting the reuptake of serotonin and norepinephrine in the brain, thereby increasing their levels. It has a particularly strong serotonergic effect, making it especially effective in managing OCD.

• Serotonin reuptake inhibition → Decreased obsessive thoughts and compulsions

• Norepinephrine effects → Improved mood and reduced anxiety

• Secondary anticholinergic and antihistaminic effects may cause certain side effects

📌 Indications and Uses

Clomipramine 25mg is prescribed for:

🔹 Psychiatric Disorders

• Obsessive-Compulsive Disorder (OCD) – first-line tricyclic agent

• Major Depressive Disorder (MDD)

• Panic disorder and phobias

• Generalized Anxiety Disorder (GAD)

🔹 Off-label Uses

• Chronic pain syndromes

• Cataplexy in narcolepsy

• Premature ejaculation

• Enuresis (bedwetting) in children (under strict medical supervision)

💊 Dosage and Administration

• Initial dose: Typically 25mg once daily (preferably at bedtime)

• Maintenance dose: Gradually increased up to 100–250mg/day in divided doses based on response and tolerance

• OCD: May require higher doses (150–250mg/day)

⚠️ Always follow doctor’s prescription and never adjust the dose without medical advice.

⚠️ Precautions and Warnings

• Use with caution in:

  • Cardiovascular disease

  • Glaucoma

  • Urinary retention

  • Seizure disorders

• Not recommended for children unless advised by a specialist

• Avoid abrupt discontinuation → may cause withdrawal symptoms like irritability, insomnia, or flu-like effects

• Should be gradually tapered when stopping

🤒 Side Effects

Common:

• Drowsiness, dizziness

• Dry mouth

• Constipation

• Blurred vision

• Increased sweating

• Weight gain

Serious (seek urgent care):

• Irregular heartbeat

• Seizures

• Severe confusion or hallucinations

• Suicidal thoughts (especially in young adults)

• Serotonin syndrome (if combined with other serotonergic drugs)

🔄 Drug Interactions

• Avoid with MAO inhibitors (can cause life-threatening reactions)

• Caution with SSRIs, SNRIs, tramadol, lithium, and antipsychotics

• Alcohol can increase sedation

• May alter the effects of antihypertensives or anticholinergic agents

🧊 Storage and Handling

• Store at room temperature (15–25°C)

• Keep away from light, heat, and moisture

• Keep out of reach of children and pets

📝 Conclusion

Clomipramine 25mg is a highly effective tricyclic antidepressant especially suited for treating OCD and depression. Though its use requires careful monitoring due to potential side effects and drug interactions, when used appropriately under medical supervision, it can significantly improve quality of life by managing intrusive thoughts, compulsions, and mood symptoms.