CLOP GM NEO CREAM

🧴🔬💥 Clotrimazole 1% + Clobetasol 0.05% + Neomycin 0.5% Cream: Triple-Action Topical for Fungal, Bacterial & Inflammatory Skin Conditions

The combination of Clotrimazole 1%, Clobetasol Propionate 0.05%, and Neomycin Sulfate 0.5% in a topical cream delivers a broad-spectrum solution for treating complex skin infections that involve fungal, bacterial, and inflammatory components. This formulation is widely prescribed for mixed skin infections, particularly where a fungal infection is accompanied by itching, inflammation, and secondary bacterial infection.

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🧪 Composition and Function

Each component serves a unique therapeutic purpose:

1. Clotrimazole (1%) – An antifungal agent from the imidazole group. It inhibits the synthesis of ergosterol, a vital component of fungal cell membranes, thereby killing or inhibiting fungal growth. Effective against:

   • Dermatophytes (e.g., Trichophyton)

   • Yeasts (e.g., Candida albicans)

   • Molds

2. Clobetasol Propionate (0.05%) – A superpotent corticosteroid. It works by reducing inflammation, redness, and itching caused by various skin conditions. It suppresses the release of inflammatory substances like prostaglandins and cytokines.

3. Neomycin Sulfate (0.5%) – A broad-spectrum aminoglycoside antibiotic. It inhibits bacterial protein synthesis, targeting gram-positive and gram-negative bacteria, helping prevent or treat secondary bacterial infections on compromised skin.

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📌 Indications and Uses

This triple-combination cream is prescribed for:

• Tinea corporis, Tinea cruris, and Tinea pedis (ringworm, jock itch, athlete’s foot)

• Intertrigo (inflammatory rash in skin folds)

• Candidiasis

• Seborrheic dermatitis

• Eczematous fungal infections

• Fungal infections with secondary bacterial infections

• Inflamed or itchy fungal rashes

Its anti-inflammatory, antifungal, and antibacterial synergy makes it ideal for short-term management of complicated or resistant skin infections.

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💊 Dosage and Application

• Apply a thin layer of the cream to the affected area twice daily, or as directed

• Use for 1 to 2 weeks or as prescribed

• Wash hands before and after application

• Avoid covering with airtight dressings unless instructed

Important: Overuse or prolonged use, especially of Clobetasol, can lead to adverse effects.

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⚠️ Precautions and Warnings

• Do not use on face, groin, or underarms unless advised

• Not recommended for long-term use due to risk of steroid-related skin thinning

• Avoid contact with eyes, mouth, and mucous membranes

• Not for children under 12 years without medical advice

• Use cautiously in pregnant or breastfeeding women

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🤒 Side Effects

Common:

• Burning, stinging, dryness

• Itching or redness at the site

Less common/serious:

• Skin thinning (atrophy)

• Stretch marks (striae)

• Secondary infections

• Allergic reactions

• Hormonal effects if used extensively (rare)

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🔄 Drug Interactions

• Avoid using with other topical steroids or antibiotics

• Risk of resistance or sensitization with prolonged neomycin use

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🧊 Storage Instructions

• Store at room temperature (15–25°C)

• Keep away from direct sunlight and heat

• Close cap tightly after use

• Keep out of reach of children

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📝 Conclusion

The combination of Clotrimazole, Clobetasol, and Neomycin offers an effective, multi-target approach to treating inflamed, itchy, and infected fungal skin conditions. However, due to the presence of a potent steroid and antibiotic, its short-term, supervised use is crucial to ensure maximum benefit and minimize risks.