COLPEP SPAS TABLET

💢💊🛠️ Drotaverine 80mg + Aceclofenac 100mg Tablet: Dual Relief for Pain & Muscle Spasms

The Drotaverine 80mg + Aceclofenac 100mg tablet is a fixed-dose combination medication used to provide rapid and effective relief from muscular pain, cramps, and inflammation. This powerful blend offers the antispasmodic benefits of Drotaverine and the anti-inflammatory, analgesic action of Aceclofenac, making it ideal for treating a wide range of painful musculoskeletal and abdominal conditions.

This dual-action therapy works synergistically to relieve pain, inflammation, and smooth muscle spasms, providing patients with quick symptomatic relief and improved comfort.

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🔬 Mechanism of Action

🔹 Drotaverine (80mg) – Antispasmodic (smooth muscle relaxant)

• Inhibits phosphodiesterase-4 enzyme (PDE4), leading to increased cyclic AMP (cAMP) levels

• Relaxes smooth muscles in the gastrointestinal, biliary, and genitourinary tracts

• Provides relief from colicky and spastic pain, such as in renal colic, dysmenorrhea, or gallbladder pain

🔹 Aceclofenac (100mg) – NSAID (Non-Steroidal Anti-Inflammatory Drug)

• Inhibits cyclooxygenase (COX-1 and COX-2) enzymes

• Blocks the synthesis of prostaglandins, chemicals responsible for pain and inflammation

• Reduces swelling, stiffness, and pain in joints and muscles

Together, they address both the underlying inflammation and the associated muscle spasms, offering comprehensive pain relief.

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📌 Indications and Uses

This combination is commonly used for:

• Menstrual cramps (dysmenorrhea)

• Renal colic (kidney stones)

• Biliary colic (gallbladder pain)

• Musculoskeletal pain

• Post-operative pain with muscle spasm

• Pelvic inflammatory pain

• Irritable bowel syndrome (IBS) with cramping

• Dental pain

Its dual mechanism makes it effective in both acute and chronic pain conditions where inflammation and spasm coexist.

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💊 Dosage and Administration

• Usual adult dose: 1 tablet twice daily, after meals

• Dosage may vary based on clinical condition and medical advice

• Take with food to minimize gastric irritation

• Not recommended for children under 12 years unless prescribed by a doctor

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⚠️ Precautions and Warnings

• Use cautiously in:

  • Patients with gastric ulcers, GERD, or bleeding disorders

  • Renal or hepatic impairment

  • Elderly patients

• Avoid in:

  • Pregnancy, especially third trimester

  • Lactation, unless clearly needed

  • Known allergy to NSAIDs or Drotaverine

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🤒 Side Effects

Common side effects:

• Gastric discomfort, nausea

• Headache or dizziness

• Dry mouth

• Mild abdominal bloating

Serious (rare):

• Gastric bleeding or ulcers (Aceclofenac-related)

• Allergic reactions (rash, swelling, difficulty breathing)

• Liver enzyme elevation

Seek immediate medical attention if you notice blood in stools, severe stomach pain, or allergic symptoms.

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🔄 Drug Interactions

• Avoid with:

  • Other NSAIDs (e.g., Ibuprofen, Diclofenac) – increased risk of GI side effects

  • Anticoagulants (e.g., warfarin) – increased bleeding risk

  • Antihypertensives – NSAIDs may reduce their effectiveness

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🧊 Storage Instructions

• Store at room temperature (15–25°C)

• Keep away from moisture, heat, and direct sunlight

• Keep out of reach of children

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📝 Conclusion

The Drotaverine 80mg + Aceclofenac 100mg tablet is a potent and fast-acting combination designed to relieve spasmodic pain accompanied by inflammation. Whether it’s renal colic, menstrual cramps, or joint pain, this dual therapy provides targeted relief, making it a valuable choice for physicians and patients managing complex pain conditions.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.