CREVAST F 10 TABLET

💊 Rosuvastatin 10mg + Fenofibrate 67mg Tablet: A Dual-Action Therapy for Lipid Control

The combination of Rosuvastatin 10mg and Fenofibrate 67mg is a powerful lipid-lowering therapy designed to treat mixed dyslipidemia—a condition where both cholesterol and triglyceride levels are abnormally high. This fixed-dose combination is particularly beneficial for patients who have elevated LDL cholesterol (bad cholesterol), high triglycerides, and low HDL (good cholesterol), which are key risk factors for cardiovascular diseases, such as heart attacks and strokes.

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🔬 Mechanism of Action

This tablet combines two complementary agents:

• Rosuvastatin (10mg): A statin that works by inhibiting HMG-CoA reductase, an enzyme responsible for cholesterol synthesis in the liver. It:

  • Reduces LDL cholesterol

  • Increases HDL cholesterol

  • Moderately lowers triglycerides

• Fenofibrate (67mg): A fibrate class medication that activates PPAR-α (Peroxisome Proliferator-Activated Receptor Alpha). This leads to:

  • Enhanced breakdown of triglyceride-rich particles

  • Reduced VLDL (very low-density lipoprotein)

  • Increased HDL cholesterol

Together, they provide synergistic lipid control, especially in patients with atherogenic dyslipidemia (high triglycerides + low HDL + moderately high LDL).

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📌 Indications and Uses

The Rosuvastatin 10mg + Fenofibrate 67mg tablet is used in the treatment of:

• Mixed dyslipidemia

• Hypercholesterolemia with elevated triglycerides

• Patients at high cardiovascular risk who need aggressive lipid management

• Dyslipidemia associated with metabolic syndrome or type 2 diabetes mellitus

It is generally prescribed when lifestyle changes and monotherapy (either statin or fibrate alone) are not sufficient to achieve target lipid levels.

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💊 Dosage and Administration

• Usual adult dose: One tablet once daily, preferably in the evening.

• Should be taken with food to enhance absorption, especially of Fenofibrate.

• Requires regular monitoring of lipid profile and liver function tests.

📌 Therapy should be individualized based on baseline lipid levels, cardiovascular risk factors, and treatment goals.

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⚠️ Precautions and Warnings

• Liver and kidney function should be assessed before and during treatment.

• Use with caution in patients with:

  • Liver disease

  • Severe renal impairment

  • Gallbladder disease

• Not recommended during pregnancy or breastfeeding.

• May increase the risk of myopathy or rhabdomyolysis, especially in elderly patients or when combined with other lipid-lowering agents.

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🤒 Side Effects

Common side effects include:

• Muscle pain or weakness

• Headache

• Abdominal discomfort

• Nausea

• Elevated liver enzymes

Serious but rare:

• Myopathy or muscle breakdown

• Liver toxicity

• Pancreatitis

• Allergic reactions

Seek immediate medical attention if you experience unexplained muscle pain, dark urine, or yellowing of the skin or eyes.

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🔄 Drug Interactions

• Increased risk of muscle damage when used with:

  • Other statins

  • Cyclosporine

  • Warfarin (may require INR monitoring)

• Alcohol may increase liver toxicity risk.

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🧊 Storage Instructions

• Store at room temperature (15–30°C)

• Keep away from moisture and direct sunlight

• Keep out of reach of children

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📝 Conclusion

Rosuvastatin 10mg + Fenofibrate 67mg is a potent dual therapy for comprehensive lipid management, targeting both cholesterol and triglycerides. It significantly reduces cardiovascular risk when used under proper medical supervision. Regular monitoring and adherence to lifestyle changes are key to maximizing its long-term benefits.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.