DABLEXA 150 CAPSULE

🩸💊⚖️ Dabigatran Etexilate 150mg: Powerful Oral Anticoagulant for Stroke and Clot Prevention

Dabigatran Etexilate 150mg is an advanced oral anticoagulant (blood thinner) used to prevent and treat blood clots in patients at risk for stroke, deep vein thrombosis (DVT), pulmonary embolism (PE), and atrial fibrillation (AF). It belongs to the class of direct thrombin inhibitors, offering a modern alternative to traditional blood thinners like warfarin.

This medication helps reduce the risk of life-threatening clots without the need for frequent blood monitoring or dietary restrictions, making it a convenient and effective option for long-term anticoagulation therapy.

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🔬 Mechanism of Action

Dabigatran is a direct thrombin inhibitor. After oral intake, it is converted into active dabigatran, which:

• Directly binds to thrombin (Factor IIa), a key enzyme in the blood clotting cascade.

• Prevents the conversion of fibrinogen to fibrin, thereby inhibiting clot formation.

• Reduces thrombus development, both in veins and heart chambers (especially in atrial fibrillation).

This direct inhibition allows for predictable anticoagulant effects and a rapid onset of action.

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📌 Indications and Uses

Dabigatran 150mg is indicated for:

🔹 Stroke and systemic embolism prevention in patients with:

• Non-valvular atrial fibrillation (AF)

🔹 Treatment and secondary prevention of:

• Deep vein thrombosis (DVT)

• Pulmonary embolism (PE)

🔹 Postoperative DVT prevention in patients undergoing:

• Hip or knee replacement surgery (typically lower doses used)

It offers a safer and more convenient alternative to warfarin with fewer interactions and no need for INR monitoring.

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💊 Dosage and Administration

• Standard dose: 150mg twice daily, with or without food.

• Dose adjustments required in:

  • Renal impairment

  • Elderly patients over 75 years

  • Patients with high bleeding risk

Swallow capsules whole; do not open, crush, or chew, as it affects drug absorption.

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⚠️ Precautions and Warnings

• Not for patients with mechanical heart valves

• Use caution in:

  • Severe renal impairment (CrCl <30 mL/min)

  • Active bleeding or bleeding disorders

  • Recent surgery or trauma

• Avoid abrupt discontinuation to prevent thrombotic events

• Antidote available: Idarucizumab for emergency reversal of anticoagulation

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🤒 Side Effects

Common:

• Bleeding (nosebleeds, bruising, gum bleeding)

• Stomach upset or pain

• Heartburn

Serious:

• Major bleeding events: gastrointestinal, intracranial

• Allergic reactions: rash, swelling, difficulty breathing

• Liver enzyme changes

Monitor patients for signs of bleeding, especially if taking other medications that increase bleeding risk (NSAIDs, antiplatelets).

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🔄 Drug Interactions

• Caution with:

  • P-glycoprotein inhibitors (e.g., amiodarone, verapamil)

  • Antiplatelets and NSAIDs (increase bleeding risk)

• Fewer food and drug interactions compared to warfarin

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🧊 Storage Instructions

• Store at 25°C, protect from moisture

• Use within 4 months of opening bottle

• Keep tightly closed and away from children

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📝 Conclusion

Dabigatran Etexilate 150mg is a revolutionary direct oral anticoagulant (DOAC) that offers effective, safe, and convenient protection against blood clots and strokes, especially in patients with atrial fibrillation or venous thromboembolism. With a predictable profile, no routine INR testing, and an available antidote, it is a key player in modern-day anticoagulant therapy.

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Always follow your doctor’s advice, dosage instructions, and never self-medicate.