DABLEXA 75 CAPSULE

🩸💊🛡️ Dabigatran Etexilate 75mg Tablet: A Modern Oral Anticoagulant for Stroke & Clot Prevention

Dabigatran Etexilate 75mg is an oral anticoagulant (blood thinner) belonging to a class known as direct thrombin inhibitors. It is commonly prescribed for the prevention and treatment of blood clots, particularly in patients with non-valvular atrial fibrillation (NVAF), deep vein thrombosis (DVT), and pulmonary embolism (PE). It is also used to prevent stroke in high-risk individuals. This lower-dose (75mg) formulation is especially important for patients with moderate renal impairment or other conditions requiring dose adjustment.

🔬 Mechanism of Action

Dabigatran Etexilate is a prodrug that, once ingested, is converted into dabigatran, its active form. Dabigatran works by directly inhibiting thrombin (Factor IIa), a key enzyme in the blood coagulation cascade. Thrombin converts fibrinogen to fibrin, leading to clot formation. By blocking thrombin:

• It prevents clot formation

• Reduces the risk of stroke and systemic embolism

• Helps breakdown existing clots in the treatment phase

This targeted mechanism gives Dabigatran a predictable anticoagulant effect, reducing the need for routine blood monitoring (unlike warfarin).

📌 Indications and Uses

Dabigatran 75mg is indicated for:

• Prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation (NVAF)

• Treatment of DVT and PE

• Prevention of recurrent DVT and PE

• Postoperative thromboprophylaxis after hip or knee replacement surgery

The 75mg dose is commonly used in:

• Patients with renal impairment (creatinine clearance 30–50 mL/min)

• Patients at higher risk of bleeding

• As a modified dose in dual antiplatelet therapy

💊 Dosage and Administration

• Typically taken twice daily with or without food

• Swallow whole, do not crush or chew the capsule, as this can increase bleeding risk

• Dose adjustments are based on renal function, age, and co-medications

In some cases, Dabigatran 75mg may be combined with aspirin or clopidogrel, but this increases bleeding risk and must be monitored carefully.

⚠️ Precautions and Warnings

• Not recommended in patients with severe renal impairment (CrCl <30 mL/min)

• Use with caution in elderly patients, and those with bleeding disorders

• Avoid use in patients with mechanical heart valves

• Discontinue before surgeries or invasive procedures (timing depends on renal function)

There is a specific reversal agent available: Idarucizumab, used in emergencies to counteract Dabigatran’s effects.

🤒 Side Effects

Common:

• Gastritis-like symptoms (indigestion, stomach pain)

• Nausea

• Minor bleeding (gums, nosebleeds, bruising)

Serious:

• Major bleeding (GI bleeding, brain hemorrhage)

• Allergic reactions (rash, swelling, difficulty breathing)

Seek medical help immediately for signs of internal bleeding or severe allergic reactions.

🔄 Drug Interactions

• Avoid with P-glycoprotein inhibitors (e.g., amiodarone, verapamil, ketoconazole) unless under supervision

• Increased bleeding risk with NSAIDs, antiplatelets, SSRIs, and other anticoagulants

Routine INR monitoring is not required, but renal function should be monitored periodically.

🧊 Storage Instructions

• Store in original blister packaging to protect from moisture

• Keep at room temperature, away from heat and direct sunlight

• Do not transfer capsules to another container

📝 Conclusion

Dabigatran Etexilate 75mg is a reliable, targeted oral anticoagulant that offers effective stroke prevention and clot treatment with minimal monitoring. Its lower dose provides a safer option for renal-impaired or elderly patients, with the convenience of oral dosing and a specific reversal agent in case of emergency.

Always follow your doctor’s advice, dosage instructions, and never self-medicate.