Description
💊 Dapagliflozin 5mg Tablets
Smart Renal Sugar Control – Start Strong with Dapagliflozin
Overview
Dapagliflozin 5mg is a once-daily oral medication used in the management of Type 2 Diabetes Mellitus. It belongs to the class of drugs called SGLT2 inhibitors (Sodium-Glucose Co-Transporter 2 inhibitors). Dapagliflozin helps lower blood glucose levels by increasing glucose excretion through the urine. It is commonly prescribed as monotherapy or in combination with other antidiabetic agents such as metformin, DPP-4 inhibitors, or insulin.
The 5mg dose is usually a starting dose, particularly for new patients or those with certain health considerations such as mild renal impairment or elderly patients.
Pharmacological Class
- SGLT2 Inhibitor (Sodium-Glucose Co-Transporter 2 Inhibitor)
Mechanism of Action
Dapagliflozin works by blocking the SGLT2 protein in the kidneys. This protein is responsible for reabsorbing glucose back into the bloodstream. By inhibiting this function:
- It increases urinary glucose excretion,
- Decreases blood sugar levels,
- Aids in weight loss,
- Slightly reduces blood pressure.
It acts independently of insulin, making it a good option even for patients with insulin resistance.
Indications
- Type 2 Diabetes Mellitus (as monotherapy or with other drugs)
- May be used with metformin, insulin, or DPP-4 inhibitors for better glucose control
- Under investigation and sometimes prescribed off-label for heart failure and chronic kidney disease under specialist care
How to Use
- Dosage: One tablet of Dapagliflozin 5mg once daily, or as directed by your healthcare provider.
- Route: Oral
- Timing: Can be taken with or without food, usually in the morning.
- Swallow the tablet whole with water. Do not chew or crush.
Hydration is important. Drink sufficient fluids to avoid dehydration, especially in hot weather or while taking diuretics.
Benefits
- Improves fasting and postprandial blood glucose levels
- Promotes weight loss in overweight patients
- Lowers systolic blood pressure
- Low risk of hypoglycemia when not used with insulin or sulfonylureas
- Simple once-daily dosing
Side Effects
- Common: Frequent urination, thirst, genital infections (especially in females), mild dehydration
- Less common: Urinary tract infections, dizziness, fatigue
- Rare but serious: Diabetic ketoacidosis (DKA), especially in very low-carb diets or with insulin use
Precautions
- Not for use in Type 1 diabetes or diabetic ketoacidosis
- Avoid in patients with moderate to severe kidney impairment (eGFR <45 mL/min/1.73m²)
- Use caution in the elderly and those on diuretics or ACE inhibitors
- Monitor kidney function and blood sugar levels regularly
Storage
- Store below 30°C, away from moisture and direct sunlight
- Keep out of reach of children
When to Contact a Doctor
- Signs of urinary tract infection (painful urination, fever)
- Symptoms of genital yeast infections
- Abdominal pain, nausea, or rapid breathing (could indicate ketoacidosis)
Conclusion
Dapagliflozin 5mg is an effective and well-tolerated option for the early and ongoing management of Type 2 Diabetes. Its insulin-independent action, weight and blood pressure benefits, and convenient once-daily dosing make it a smart starting point for modern diabetes care.