💊 Dapagliflozin 10mg + Sitagliptin 100mg Tablets
Dual Innovation for Diabetes – Smart Control Without Compromise
Overview
Dapagliflozin 10mg + Sitagliptin 100mg is an oral fixed-dose combination medication used for the treatment of Type 2 Diabetes Mellitus in adults. It is prescribed when blood sugar levels are not well controlled with diet, exercise, and single-agent therapy. This dual-drug combination provides complementary mechanisms to help manage blood sugar more effectively throughout the day, especially post-meal and fasting glucose levels.
Drug Class
- Dapagliflozin – SGLT2 Inhibitor
- Sitagliptin – DPP-4 Inhibitor
Mechanism of Action
- Dapagliflozin (10 mg)
- Acts by blocking sodium-glucose co-transporter 2 (SGLT2) in the kidneys.
- This helps reduce glucose reabsorption, promoting glucose excretion through urine.
- Also leads to mild weight loss and blood pressure reduction.
- Sitagliptin (100 mg)
- Inhibits the DPP-4 enzyme, which increases levels of incretin hormones.
- These hormones enhance insulin secretion and reduce glucagon production in response to food intake.
- Primarily helps in postprandial blood sugar control.
Together, they provide a powerful dual mechanism targeting both fasting and post-meal glucose levels.
Indications
- Adults with Type 2 Diabetes Mellitus
- Inadequate glycemic control with monotherapy or other oral antidiabetics
- As an adjunct to diet and physical activity
How to Use
- Dosage: Typically once daily, or as prescribed by your healthcare provider.
- Route: Oral (by mouth)
- Timing: Can be taken with or without food, preferably at the same time each day.
- Administration: Swallow the tablet whole with water. Do not split, crush, or chew.
Maintain adequate hydration throughout therapy.
Benefits
- Dual mechanism for more effective blood glucose control
- Supports weight reduction (due to dapagliflozin)
- Convenient once-daily dosing
- Low risk of hypoglycemia when used alone
- Helps in post-meal and fasting blood sugar control
Side Effects
- Dapagliflozin: Frequent urination, urinary or genital infections, dehydration
- Sitagliptin: Headache, upper respiratory symptoms, rarely pancreatitis
- Other rare effects: Joint pain, dizziness, fatigue
Seek immediate help if you experience symptoms like severe abdominal pain, allergic reactions, or signs of ketoacidosis.
Precautions
- Not for use in Type 1 diabetes or diabetic ketoacidosis
- Avoid in patients with severe kidney impairment
- Use caution in elderly, dehydrated patients, or those taking diuretics
- Regularly monitor blood glucose levels, kidney function, and HbA1c
Storage
- Store below 30°C in a cool, dry place
- Keep out of reach of children and away from moisture
When to Contact a Doctor
- Symptoms of low blood sugar (dizziness, hunger, confusion)
- Signs of urinary infection or genital irritation
- Sudden abdominal pain or breathing difficulty
Conclusion
Dapagliflozin + Sitagliptin provides a well-balanced, dual-acting therapy that simplifies diabetes management. It offers broad coverage of both fasting and post-meal glucose levels while also supporting weight and blood pressure benefits. Ideal for patients requiring intensification beyond single therapy, it fits into a long-term, patient-friendly diabetes management plan.
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