Description
💊 Dapagliflozin 5mg + Metformin 1000mg Tablets
Dual Power, Daily Control – Modern Therapy for Type 2 Diabetes
Overview
Dapagliflozin 5mg + Metformin 1000mg is an oral fixed-dose combination medication used in the management of Type 2 Diabetes Mellitus. It brings together two highly effective antidiabetic agents from different pharmacological classes, offering complementary actions for better glycemic control. This combination is often prescribed for adults whose blood sugar is not adequately controlled with diet, exercise, and either agent alone.
This combination is especially beneficial for patients requiring moderate intensification of therapy while keeping treatment convenient and simple with once- or twice-daily dosing.
Pharmacological Classes
- Dapagliflozin (5mg) – SGLT2 Inhibitor
- Metformin (1000mg) – Biguanide
Mechanism of Action
🧪 Dapagliflozin
- Blocks SGLT2 (sodium-glucose co-transporter 2) in the kidneys.
- Reduces glucose reabsorption, allowing more sugar to be excreted through the urine.
- Results in lower blood sugar, weight loss, and mild blood pressure reduction.
🧬 Metformin
- Reduces hepatic glucose production.
- Increases insulin sensitivity.
- Enhances peripheral glucose uptake and utilization.
Together, they provide a dual-action approach—tackling glucose at the source and increasing its clearance from the body.
Indications
- Type 2 Diabetes Mellitus in adults
- When blood sugar is not adequately controlled by metformin alone or other oral agents
- As part of a complete treatment plan including diet and exercise
How to Use
- Dosage: Typically one tablet once or twice daily as prescribed by your physician.
- Route: Oral
- Administration: Take with meals to reduce gastrointestinal side effects (especially from metformin).
- Swallow whole with water. Do not crush or chew.
Maintain adequate hydration during treatment, especially while using dapagliflozin.
Benefits
- Targets multiple glucose pathways—production, reabsorption, and sensitivity
- Effective control of fasting and postprandial blood glucose
- May support weight loss and lower blood pressure
- Low risk of hypoglycemia when not used with insulin or sulfonylureas
- Convenient dosing improves adherence and outcomes
Side Effects
- Metformin: Nausea, bloating, diarrhea (improves over time)
- Dapagliflozin: Increased urination, urinary tract infections, genital yeast infections, dehydration
- Rare but serious: Lactic acidosis (metformin), ketoacidosis (dapagliflozin)
Precautions
- Not for use in Type 1 diabetes or diabetic ketoacidosis
- Avoid in patients with moderate-to-severe kidney disease
- Use caution in elderly or those on diuretics/ACE inhibitors
- Regular monitoring of blood glucose, kidney function, and HbA1c is recommended
- Avoid excessive alcohol intake
Storage
- Store below 30°C in a dry place
- Keep out of reach of children
- Protect from direct sunlight and moisture
When to Contact a Doctor
- Persistent vomiting or diarrhea
- Symptoms of urinary or genital infections
- Muscle pain, weakness, or signs of lactic acidosis
- Shortness of breath, dizziness, or unusual fatigue
Conclusion
Dapagliflozin 5mg + Metformin 1000mg is a smart, effective, and well-tolerated combination therapy for Type 2 Diabetes. With its dual action, weight and blood pressure benefits, and convenient dosing, it supports both metabolic control and long-term outcomes when used with proper lifestyle management.
