Description
Overview
Rabeprazole 20mg + Levosulpiride 75mg is a combination medication commonly used to treat gastrointestinal conditions like gastroesophageal reflux disease (GERD), non-ulcer dyspepsia, and functional dyspepsia. It is also effective in managing conditions involving excess stomach acid and motility disorders.
Active Ingredients & How They Work
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Rabeprazole (20mg)
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Class: Proton Pump Inhibitor (PPI)
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Function: Reduces stomach acid production by blocking the H⁺/K⁺-ATPase enzyme in gastric parietal cells.
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Levosulpiride (75mg)
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Class: Atypical antipsychotic and prokinetic agent
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Function: Enhances gastrointestinal motility and exerts antiemetic (anti-vomiting) and antipsychotic effects by blocking dopamine D2 receptors.
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Indications (Uses)
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GERD (acid reflux)
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Functional dyspepsia
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Nausea and bloating
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Non-ulcer stomach pain
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Gastritis with delayed gastric emptying
How to Use
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Dosage: One capsule daily, preferably before meals, or as prescribed by a doctor.
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Duration: Based on the underlying condition; often 2 to 8 weeks.
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Form: Swallow whole with water; do not crush or chew.
Common Side Effects
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Nausea
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Headache
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Constipation or diarrhea
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Drowsiness or dizziness
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Flatulence
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Mild abdominal pain
Serious Side Effects (Seek Medical Help)
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Irregular heartbeat or palpitations
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Severe dizziness or fainting
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Muscle spasms or tremors
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Persistent diarrhea (risk of Clostridium difficile infection)
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Signs of high prolactin (e.g., breast enlargement, menstrual irregularities)
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Allergic reaction (rash, swelling, trouble breathing)
Monitoring & Follow-Up
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Periodic liver function tests
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Electrolyte levels (e.g., magnesium, calcium) for long-term use
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Assessment of gastrointestinal symptoms (for efficacy)
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Prolactin levels (if symptoms suggest hormonal imbalance)
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Mental health review, especially in patients with anxiety or depression history
Warnings & Precautions
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Pregnancy & Breastfeeding: Use only if clearly needed; consult a doctor.
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CNS Effects: May cause drowsiness or dizziness; avoid driving or operating heavy machinery.
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Chronic Use: Long-term use may lead to vitamin B12 deficiency or osteoporosis-related fractures.
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Pre-existing Conditions: Use cautiously in patients with epilepsy, Parkinson’s disease, or liver disease.
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Drug Interactions: Avoid alcohol and consult with your doctor if taking other medications (e.g., antipsychotics, antiepileptics, anticoagulants).
Summary
Rabeprazole + Levosulpiride 20/75mg capsules offer dual action: acid suppression and enhanced gastric motility, making them effective in managing acid reflux and dyspeptic symptoms. Though well tolerated, monitoring is crucial for long-term safety, especially regarding neurological and hormonal effects. Always use under medical supervision, and report unusual symptoms promptly.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.
