DERICIP TABLET

🌬️ Etofylline 77mg + Theophylline 23mg Tablet: Dual Bronchodilator for Respiratory Relief

Etofylline 77mg + Theophylline 23mg is a combination medication used as a bronchodilator to treat and manage various chronic respiratory conditions like asthma, chronic obstructive pulmonary disease (COPD), bronchitis, and emphysema. This formulation combines two methylxanthine derivatives—Etofylline and Theophylline—which work synergistically to relax the airway muscles, improve breathing capacity, and reduce airway inflammation.

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🔬 Mechanism of Action

Both components belong to the xanthine class of bronchodilators, and together they enhance therapeutic effect while reducing the individual dose of each, minimizing side effects.

🔹 Theophylline (23mg)

• Inhibits phosphodiesterase (PDE), leading to an increase in cyclic AMP (cAMP)

• Results in bronchial smooth muscle relaxation, improved airflow

• Also has mild anti-inflammatory and diuretic effects

🔹 Etofylline (77mg)

• A derivative of theophylline with better gastrointestinal tolerance

• Enhances bronchodilatory effects

• Reduces airway hyperresponsiveness

• May improve oxygen utilization in tissues

Combined, they reduce airway resistance, improve ventilation, and help relieve wheezing, chest tightness, and shortness of breath.

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📌 Indications and Uses

This combination is used in the management of chronic and acute respiratory conditions, such as:

• Bronchial asthma

• Chronic obstructive pulmonary disease (COPD)

• Chronic bronchitis

• Emphysema

• Airway obstruction associated with allergies or infection

It is often prescribed when inhalers or steroids alone are insufficient or when patients require oral maintenance therapy.

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💊 Dosage and Administration

• Typical adult dose: One tablet 2 to 3 times daily, as directed by the physician

• Should be taken after food to avoid gastric irritation

• Do not crush or chew extended-release formulations

Dosage may be adjusted based on age, body weight, and severity of symptoms. Regular monitoring is recommended in long-term use.

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⚠️ Precautions and Warnings

• Use with caution in patients with:

  • Cardiac arrhythmias

  • Hypertension

  • Peptic ulcer

  • Hyperthyroidism

  • Seizure disorders

• Requires dose adjustment in liver or kidney impairment

• Not recommended in children unless prescribed by a pediatrician

Avoid alcohol and smoking, as they may interfere with drug metabolism.

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🤒 Side Effects

Common:

• Nausea

• Stomach upset

• Headache

• Restlessness

• Insomnia

Serious but rare:

• Heart palpitations

• Seizures (with overdose)

• Hypotension

• Allergic reactions

Promptly report symptoms like fast heartbeat, dizziness, or difficulty breathing to a doctor.

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🔄 Drug Interactions

• Caution with:

  • Antibiotics (e.g., erythromycin, ciprofloxacin)

  • Beta-blockers

  • Diuretics

  • Anti-epileptics

• Smoking and certain foods (e.g., caffeine) can affect theophylline levels

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🧊 Storage Instructions

• Store at 15–25°C, in a dry, cool place

• Protect from light and moisture

• Keep out of reach of children

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📝 Conclusion

Etofylline 77mg + Theophylline 23mg tablet offers a potent oral bronchodilator option for patients with persistent or severe respiratory symptoms. By combining two xanthine derivatives, it enhances airflow, reduces dyspnea, and improves quality of life in chronic lung conditions. When used as directed and monitored appropriately, it can be a safe and effective therapy for long-term respiratory management.