DERIPHYLIN RETARD 150 TABLET

🌬️ Etofylline 115mg + Theophylline 35mg Tablet: Dual Bronchodilator Therapy for Respiratory Relief

The combination of Etofylline 115mg and Theophylline 35mg is a widely used oral bronchodilator formulation designed to treat chronic and acute respiratory conditions such as bronchial asthma, chronic obstructive pulmonary disease (COPD), chronic bronchitis, and emphysema. This dual-action therapy improves airflow, eases breathing, and reduces the frequency and severity of respiratory symptoms like wheezing, chest tightness, and shortness of breath.

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🔬 Mechanism of Action

Both Etofylline and Theophylline belong to the methylxanthine class of bronchodilators, and they work synergistically to relax bronchial smooth muscles, thereby widening the airways and improving oxygen flow.

🔹 Etofylline (115mg)

• A derivative of theophylline, more water-soluble

• Has faster onset of action

• Enhances the bronchodilator effect and reduces airway resistance

🔹 Theophylline (35mg)

• Acts as a phosphodiesterase inhibitor, increasing cAMP levels, which leads to smooth muscle relaxation

• Stimulates the respiratory center in the brain, improving breathing rate

• Possesses anti-inflammatory and mild diuretic properties

Together, they provide symptomatic relief in obstructive airway diseases by improving lung function and enhancing mucociliary clearance.

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📌 Indications and Uses

The Etofylline + Theophylline combination is used in the treatment and prevention of:

• Bronchial asthma

• Chronic Obstructive Pulmonary Disease (COPD)

• Chronic bronchitis

• Emphysema

• Nighttime asthma attacks

• Exercise-induced bronchospasm

It may also be used as an add-on therapy when inhalers or corticosteroids alone do not provide sufficient relief.

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💊 Dosage and Administration

• Usual adult dose: 1 tablet two or three times daily, after meals

• Should be taken with water, and not on an empty stomach to reduce gastric irritation

• Dose should be individualized based on age, weight, and renal/hepatic function

In elderly patients or those with liver/kidney impairment, dose adjustments may be necessary to avoid accumulation and toxicity.

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⚠️ Precautions and Warnings

• Avoid in patients with:

  • Seizure disorders

  • Severe liver or kidney impairment

  • Cardiac arrhythmias

  • Peptic ulcers

• Caution in:

  • Elderly patients

  • Children under 12 years (dose adjustment required)

  • Hypertensive patients

Regular monitoring of theophylline levels may be required in long-term therapy to avoid toxicity.

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🤒 Side Effects

Common:

• Nausea, vomiting

• Headache

• Insomnia or restlessness

• Gastric irritation

Serious (dose-dependent or prolonged use):

• Heart palpitations

• Seizures

• Arrhythmias

• Hypotension

• Central nervous system stimulation

Seek immediate care in case of irregular heartbeat, severe dizziness, or seizure-like symptoms.

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🔄 Drug Interactions

• Avoid concurrent use with:

  • Macrolide antibiotics (e.g., erythromycin)

  • Fluoroquinolones

  • Cimetidine

  • Beta-blockers

• Smoking and alcohol may alter theophylline metabolism

Always inform your doctor about all medications being taken.

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🧊 Storage Instructions

• Store at room temperature (15–25°C)

• Protect from light, heat, and moisture

• Keep out of reach of children

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📝 Conclusion

The Etofylline 115mg + Theophylline 35mg tablet offers fast, effective relief from bronchial spasms and respiratory distress in conditions like asthma and COPD. Its dual mechanism makes it a valuable option in cases where inhaled therapies alone aren’t sufficient. With proper medical supervision and dosage control, it helps patients breathe easier and live better.