💊 Overview

This tablet is a dual-action painkiller that combines the anti-inflammatory effects of diclofenac with the pain-relieving and fever-reducing properties of paracetamol. It is commonly prescribed for musculoskeletal pain, dental pain, joint inflammation, and fever with pain.

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🧪 Ingredients & Mechanism of Action

1. Diclofenac Sodium (50 mg) – A non-steroidal anti-inflammatory drug (NSAID) that reduces inflammation, swelling, and pain by inhibiting cyclooxygenase (COX) enzymes, thereby reducing prostaglandin synthesis.

2. Paracetamol (325 mg) – An analgesic and antipyretic that raises the pain threshold and reduces fever by acting on the hypothalamic heat-regulating center.

Combined Action:
This combination provides faster and more effective pain relief with reduced gastrointestinal side effects compared to diclofenac alone.

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✅ Indications / Uses

• Headache, migraine

• Dental pain and post-dental surgery pain

• Joint pain: osteoarthritis, rheumatoid arthritis

• Muscular pain, sprains, and strains

• Menstrual cramps

• Back pain, sciatica

• Fever with body aches

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📋 How to Use

• Typical Dose: 1 tablet two to three times daily, after food.

• Route: Oral, with a full glass of water.

• Duration: Use for short-term relief unless advised otherwise.

• Do not exceed the maximum daily dose of paracetamol (4,000 mg/day) or diclofenac.

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⚠️ Common Side Effects

• Gastric discomfort or acidity

• Nausea or vomiting

• Headache

• Dizziness

• Drowsiness

• Indigestion or bloating

These side effects are generally mild and short-lived.

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🚨 Serious Side Effects (Seek Immediate Help)

• Gastrointestinal bleeding (black stools, vomiting blood)

• Liver damage (yellowing of eyes/skin, dark urine, fatigue)

• Allergic reaction (rash, itching, swelling, difficulty breathing)

• Kidney dysfunction (reduced urine output, swelling in legs)

• Severe abdominal pain or persistent nausea

• High blood pressure or cardiac symptoms (rare, but possible with long-term use)

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🔍 Monitoring & Follow-Up

• Liver Function Tests (LFTs): Recommended if used regularly

• Renal Function Tests (KFTs): In elderly or long-term users

• Blood Pressure Monitoring: If used long term, especially in hypertensive patients

• GI Monitoring: Watch for signs of ulcers or bleeding

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⚠️ Warnings & Precautions

• Liver Disease: Use with caution; paracetamol is hepatotoxic in overdose

• Kidney Impairment: NSAIDs can worsen renal function

• Stomach Ulcers or GI Bleeding: Avoid or use under strict supervision

• Pregnancy & Breastfeeding: Avoid in late pregnancy; use only under medical advice

• Alcohol Use: Increases risk of liver damage — avoid

• Elderly Patients: Increased risk of GI and kidney side effects

• Drug Interactions: Avoid using with other NSAIDs, blood thinners, or other paracetamol-containing medications

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📝 Summary

The Diclofenac 50mg + Paracetamol 325mg tablet is a widely used, fast-acting, and effective treatment for mild to moderate pain and inflammation. It offers the benefits of reduced swelling, relief from pain, and control of fever in a single dose. However, due to potential liver, kidney, and gastrointestinal risks, it should be used for short-term relief under medical supervision. Regular monitoring is essential for safe long-term use.

Consult your doctor before use and never self-medicate.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.