Sale!

DOXOFYL 400 TABLET

Original price was: ₹99.00.Current price is: ₹84.15.

DOXOFYL 400 TABLET

Doxofylline 400mg

Medispan Ltd

๐ŸŒฌ๏ธ Doxofylline 400mg Tablet: A Modern Bronchodilator for Easier Breathing

Overview

Doxofylline 400mg is a methylxanthine derivative used as a bronchodilator for the treatment of asthma, chronic obstructive pulmonary disease (COPD), and other respiratory conditions involving bronchospasm. It is structurally related to theophylline but has significant clinical advantages, including fewer side effects and a better safety profile.

Doxofylline helps relax the smooth muscles of the airways, making breathing easier for patients suffering from obstructive lung diseases. It is especially favored for long-term management in patients who cannot tolerate the side effects of older xanthines like theophylline.


๐Ÿ’Š Composition and Mechanism of Action

  • Active ingredient: Doxofylline 400mg

  • Drug class: Xanthine derivative (non-selective phosphodiesterase inhibitor)

Doxofylline works by inhibiting phosphodiesterase (PDE) enzymes, particularly PDE-3 and PDE-4, leading to increased intracellular cyclic AMP (cAMP) levels. This causes relaxation of bronchial smooth muscles, leading to bronchodilation. Unlike theophylline, doxofylline has minimal action on adenosine receptors, reducing the risk of cardiac and central nervous system side effects.

It also has mild anti-inflammatory properties, which help reduce airway inflammation in chronic respiratory diseases.


๐Ÿงช Therapeutic Uses

Doxofylline 400mg is primarily used for:

  • Bronchial asthma (acute or chronic)

  • Chronic obstructive pulmonary disease (COPD)

  • Chronic bronchitis with wheezing

  • Emphysema

It may be used alone or in combination with other bronchodilators and corticosteroids as part of a comprehensive respiratory care regimen.


๐Ÿ“‹ Dosage and Administration

  • Usual adult dose: One tablet (400mg) once or twice daily, depending on severity and patient response.

  • Route: Oral

  • Timing: Preferably taken after meals to reduce gastrointestinal irritation.

Dose adjustments may be needed in elderly patients or those with liver dysfunction. Always follow the physicianโ€™s instructions regarding dosage and duration.


โš ๏ธ Side Effects and Precautions

Common side effects:

  • Nausea

  • Stomach discomfort

  • Headache

  • Insomnia

  • Nervousness (less common than with theophylline)

Less common but serious effects:

  • Rapid heartbeat (tachycardia)

  • Hypotension

  • Seizures (rare and mostly associated with overdose)

Precautions:

  • Use cautiously in patients with cardiovascular disease, seizure disorders, or liver dysfunction.

  • Monitor serum drug levels if co-administered with other xanthines.

  • Pregnancy & lactation: Use only if clearly needed and under medical supervision.


๐Ÿ”„ Drug Interactions

  • Minimal interaction with cytochrome P450 enzymes, making it safer than theophylline in patients on multiple medications.

  • However, caution is advised when taken with other CNS stimulants or beta-agonists.

  • Alcohol can increase the risk of side effects and should be avoided.


๐Ÿ“ Final Thoughts

Doxofylline 400mg tablet is a safe and effective bronchodilator for long-term management of asthma and COPD. With its reduced side-effect profile compared to older methylxanthines, it offers a better quality of life for patients who need sustained bronchodilation. It should be used under medical supervision and as part of a comprehensive respiratory treatment plan, including inhalers and lifestyle changes for optimal outcomes.

Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.

Tablet

Reviews

There are no reviews yet.

Be the first to review “DOXOFYL 400 TABLET”

Your email address will not be published. Required fields are marked *

Shopping Cart
Scroll to Top