Description
Dual Action Relief from Pain, Spasms & Cramps
💊 Composition (Per Tablet)
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Drotaverine Hydrochloride – 80 mg
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Mefenamic Acid – 250 mg
🧠 Overview
SPASMEF-D™ Tablet is a potent combination therapy designed to provide fast and effective relief from smooth muscle spasms, dysmenorrhea, renal and biliary colic, and other pain conditions associated with muscle contractions and inflammation. The synergistic action of Drotaverine, a powerful antispasmodic, and Mefenamic Acid, a nonsteroidal anti-inflammatory drug (NSAID), makes it a comprehensive choice for spasmolytic and analgesic relief.
🔬 Mechanism of Action
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Drotaverine:
A selective phosphodiesterase-4 (PDE4) inhibitor, Drotaverine increases intracellular cyclic AMP (cAMP) levels in smooth muscle cells, leading to muscle relaxation. It relieves painful spasms in the gastrointestinal, genitourinary, and biliary tracts without affecting heart rate or blood pressure. -
Mefenamic Acid:
An NSAID that works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, reducing the production of prostaglandins, which cause inflammation, pain, and fever. It also has mild antipyretic and anti-inflammatory effects, complementing the spasmolytic action of Drotaverine.
Together, they address both the spasmodic cause of pain and the inflammatory response, ensuring fast, long-lasting relief.
🎯 Indications
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Dysmenorrhea (painful menstruation)
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Renal colic
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Biliary colic
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Intestinal spasms and colitis
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Ureteric or bladder spasms
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Post-surgical or injury-related muscle pain
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Functional gastrointestinal disorders
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Pain associated with inflammatory conditions
✅ Key Benefits
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Rapid dual relief from both spasm and pain
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Relaxes smooth muscles across different organ systems
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Reduces prostaglandin-induced inflammation and discomfort
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Effective in treating acute episodes and chronic spasmodic conditions
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Well-tolerated when taken as per dosage guidelines
💊 Dosage & Administration
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Adults: 1 tablet two to three times daily after meals, or as directed by a physician
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Not recommended for children under 12 years unless specifically advised
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Adequate fluid intake is recommended during treatment
⚠️ Precautions & Side Effects
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Common Side Effects: Nausea, dry mouth, headache, drowsiness, abdominal discomfort
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Serious (rare): Hypersensitivity, peptic ulcers, renal function changes
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Contraindicated in patients with:
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Known allergy to NSAIDs
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Severe liver, kidney, or cardiac dysfunction
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History of gastrointestinal bleeding or peptic ulcer
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Avoid alcohol and other NSAIDs during therapy
🛡️ Storage
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Store at room temperature (below 25°C)
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Protect from direct sunlight and moisture
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Keep out of reach of children
📝 Conclusion
SPASMEF-D™ Tablet provides powerful, dual-action relief from painful spasms and inflammation. Its unique combination of Drotaverine’s muscle-relaxing properties and Mefenamic Acid’s pain-killing effects makes it a reliable and effective therapy for a wide range of conditions involving spasm and pain—restoring comfort and functionality quickly.
Note: This information is intended for educational purposes and should not replace professional medical advice. Always consult a healthcare provider for personalized guidance.
